Volkovová K, Chorváthová V, Jurcovicová M, Koszeghyová L, Bobek P
Research Institute of Nutrition, Bratislava, Slovak Republic.
Physiol Res. 1993;42(4):251-5.
The influence of acute diabetes (8 days), induced by streptozotocin (45 mg.kg-1 body weight) on myocardial and renal antioxidative conditions was investigated. The animals were given subtherapeutical doses of insulin (Interdep 6 U. kg-1 body weight, s.c.). Considerably increased levels of malondialdehyde (MDA), as well as of superoxide dismutase (SOD) and catalase (CAT) activity were found in the myocardium of diabetic animals. The oxidized glutathione (GSSG) level and glutathione peroxidase (GSH-PX) activity remained unchanged. The reduced glutathione (GSH) level as well as the activity of glutathione S-transferase (GST) were significantly lower. The activity of GSH-PX in the kidneys of diabetic rats increased by 60% and that of GST by 105%, respectively. CAT and SOD activity values were unchanged.
研究了链脲佐菌素（45mg·kg-1体重）诱导的急性糖尿病（8天）对心肌和肾脏抗氧化状态的影响。给动物皮下注射低于治疗剂量的胰岛素（Interdep 6U·kg-1体重）。在糖尿病动物的心肌中发现丙二醛（MDA）水平以及超氧化物歧化酶（SOD）和过氧化氢酶（CAT）活性显著升高。氧化型谷胱甘肽（GSSG）水平和谷胱甘肽过氧化物酶（GSH-PX）活性保持不变。还原型谷胱甘肽（GSH）水平以及谷胱甘肽S-转移酶（GST）活性显著降低。糖尿病大鼠肾脏中GSH-PX的活性分别增加了60%，GST的活性增加了105%。CAT和SOD活性值未发生变化。
