Department of Bioengineering, Imperial College London, London, UK.
J Invest Dermatol. 2013 Jun;133(6):1472-8. doi: 10.1038/jid.2013.69. Epub 2013 Mar 21.
Mathematical modeling is a promising approach to reveal disease-related regulatory mechanisms. This article gives an overview of how mathematical modeling can increase our understanding of skin disease, addressing both its benefits and challenges. We discuss the importance of strong links among experiments, mathematical modeling, and data analysis in order to effectively use the modeling approach to advance skin research in the postgenomic era. Investigative dermatologists are needed to drive and orient this cross-disciplinary research to address fundamental problems in skin biology and disease.
数学建模是揭示疾病相关调控机制的一种很有前途的方法。本文概述了数学建模如何提高我们对皮肤病的认识，既讨论了其优势也讨论了其挑战。我们讨论了在实验、数学建模和数据分析之间建立牢固联系的重要性，以便在后基因组时代有效地利用建模方法推进皮肤研究。需要有研究皮肤病学的人员来推动和指导这种跨学科研究，以解决皮肤生物学和疾病中的基本问题。
