Dokmeci Elif, Herrick Christina A
Department of Pediatrics, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Semin Cutan Med Surg. 2008 Jun;27(2):138-43. doi: 10.1016/j.sder.2008.04.006.
Atopic dermatitis (AD) is a chronic inflammatory skin disease with a complex pathogenesis. It is clinically well-defined and represents one manifestation of the atopic state, along with asthma, food allergy and/or allergic rhinitis. Within the last several decades, there has been much evidence to support the contribution of immune mechanisms in the pathogenesis of AD. It has also been documented that the prevalence of all atopic disease, including AD, has been increasing, although the environmental factors that may be contributing to this increase are not clearly defined. A better understanding of the underlying immunopathogenesis of AD should aid in better clinical management and development of new treatment options.
特应性皮炎（AD）是一种发病机制复杂的慢性炎症性皮肤病。它在临床上有明确的定义，是特应性状态的一种表现形式，与哮喘、食物过敏和/或过敏性鼻炎一同出现。在过去几十年里，有大量证据支持免疫机制在AD发病机制中的作用。也有文献记载，包括AD在内的所有特应性疾病的患病率一直在上升，尽管尚不明确可能导致这种上升的环境因素。更好地理解AD潜在的免疫发病机制应有助于改善临床管理并开发新的治疗方案。
