Driscoll Tim, Dyer Matthew D, Murali T M, Sobral Bruno W
Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Nucleic Acids Res. 2009 Jan;37(Database issue):D647-50. doi: 10.1093/nar/gkn799. Epub 2008 Nov 4.
Protein-protein interactions (PPIs) play a vital role in initiating infection in a number of pathogens. Identifying which interactions allow a pathogen to infect its host can help us to understand methods of pathogenesis and provide potential targets for therapeutics. Public resources for studying host-pathogen systems, in particular PPIs, are scarce. To facilitate the study of host-pathogen PPIs, we have collected and integrated host-pathogen PPI (HP-PPI) data from a number of public resources to create the Pathogen Interaction Gateway (PIG). PIG provides a text based search and a BLAST interface for searching the HP-PPI data. Each entry in PIG includes information such as the functional annotations and the domains present in the interacting proteins. PIG provides links to external databases to allow for easy navigation among the various websites. Additionally, PIG includes a tool for visualizing a single HP-PPI network or two HP-PPI networks. PIG can be accessed at http://pig.vbi.vt.edu.
蛋白质-蛋白质相互作用（PPIs）在许多病原体引发感染的过程中起着至关重要的作用。确定哪些相互作用能使病原体感染其宿主有助于我们理解发病机制，并为治疗提供潜在靶点。用于研究宿主-病原体系统，特别是PPIs的公共资源稀缺。为便于研究宿主-病原体PPIs，我们从多个公共资源中收集并整合了宿主-病原体PPI（HP-PPI）数据，以创建病原体相互作用网关（PIG）。PIG提供基于文本的搜索和用于搜索HP-PPI数据的BLAST界面。PIG中的每个条目都包含诸如功能注释和相互作用蛋白中存在的结构域等信息。PIG提供指向外部数据库的链接，以便在各个网站之间轻松导航。此外，PIG还包括一个用于可视化单个HP-PPI网络或两个HP-PPI网络的工具。可通过http://pig.vbi.vt.edu访问PIG。
