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普拉西丁,链霉菌属Q-1043产生的血小板聚集抑制剂。I. 发酵、分离及生物学特性

Placetins, platelet aggregation inhibitors from Streptomyces sp. Q-1043. I. Fermentation, isolation and biological properties.

作者信息

Ozasa T, Suzuki K, Yamada T, Suzaki K, Nohara C, Kobori M, Saito T

机构信息

Central Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1990 Apr;43(4):331-5. doi: 10.7164/antibiotics.43.331.

Abstract

Placetins, platelet aggregation inhibitors were obtained from the culture broth of Streptomyces sp. Q-1043. These were designated placetins A, A1, B and B1, respectively. Placetins A and B showed strong cytotoxicities against P388, L1210 and HeLa cells.

摘要

血小板聚集抑制剂普拉西丁是从链霉菌属Q-1043的培养液中获得的。它们分别被命名为普拉西丁A、A1、B和B1。普拉西丁A和B对P388、L1210和HeLa细胞表现出很强的细胞毒性。

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