Wagner V, Wagnerová M, Zavázal V, Kríz J
Regional Hygienic Station StKNV, Prague, Czechoslovakia.
J Hyg Epidemiol Microbiol Immunol. 1990;34(1):17-26.
In four areas with different types of atmospheric pollution 534 children of school age were examined for serum immunoglobulins (IgG, IgA, IgM and IgE), saliva IgA (sIgA), lysozymes (LYS) and acute phase reactants (alfa-l-antitrypsin - A1AT, alfa-2-macroglobulin -A2M, ceruloplasmin -CPL, transferrin - TRF). The children were divided into two groups: those with altered resistance (AR) comprising allergoses of all types and recurrent or persistent infections and those without the above health problems, i.e. healthy (H). There were more children with AR in areas with higher atmospheric pollution than in control areas. The frequency of AR was higher among boys than among girls. In the control area BN, a number of parameters in the AR group differed significantly from those in the H group. In areas with substantial atmospheric pollution these differences were generally less pronounced. Significant differences were found between the control and polluted areas in many indicators. In the area KO characterized by an intermediate degree of industrial pollution the means of the tested parameters were habitually elevated, whereas in the heavily polluted areas they were decreased. The most sensitive tests for evaluating differences between the areas were the levels of A1AT, LYS, and IgE, while the variations of sIgA, sLYS and CPL were less pronounced.
在4个存在不同类型大气污染的地区，对534名学龄儿童进行了血清免疫球蛋白（IgG、IgA、IgM和IgE）、唾液IgA（sIgA）、溶菌酶（LYS）及急性期反应物（α1抗胰蛋白酶 - A1AT、α2巨球蛋白 - A2M、铜蓝蛋白 - CPL、转铁蛋白 - TRF）的检测。这些儿童被分为两组：抵抗力改变组（AR），包括所有类型的过敏症以及反复或持续感染的儿童；另一组是没有上述健康问题的儿童，即健康组（H）。大气污染程度较高地区的AR儿童比对照地区更多。AR在男孩中的发生率高于女孩。在对照地区BN，AR组的一些参数与H组有显著差异。在大气污染严重的地区，这些差异通常不太明显。在许多指标上，对照地区和污染地区之间存在显著差异。在工业污染程度中等的KO地区，所测参数的均值通常升高，而在污染严重的地区则降低。评估地区间差异最敏感的检测指标是A1AT、LYS和IgE的水平，而sIgA、sLYS和CPL的变化则不太明显。
