Wagnerová M, Wagner V, Mádlo Z, Zavázal V, Wokounová D, Kríz J, Mohyla O
J Hyg Epidemiol Microbiol Immunol. 1986;30(2):127-38.
A semicohort of children, initial age about 11.5 years, from an exposure area near a secondary lead smelting plant (E group children) was examined for some humoral immune response parameters in the blood and saliva and compared to a group of control children matched by age living in a relatively unpolluted rural area (Co group children). All examinations were performed every autumn and spring over a period of 2 successive years, and the data included in the final analysis were only from children who had completed at least 3 of the 4 examination series performed. To sum up, children from area E showed a clearcut elevation of mean blood lead (Pb) levels with marked seasonal fluctuations peaking in spring; Pb levels in the blood of Co group children had no such season-related fluctuation patterns and tended to slightly decline over the two years of observation. Delta-aminolevulinic acid dehydratases (ALAD) levels in area E were of distinctly lower mean values than in area Co, but no correlation with mean blood Pb levels could be observed. Levels of IgG were more or less inversely correlative with Pb levels in both sexes, levels of IgM showed a distinct downward trend in E group children at all samplings. Total serum protein (SP) levels of children from area E showed a reverse correlation with plumbemia, secretory IgA (sIgA) concentrations showed a decrease in E group children of both sexes, but the values tended to converge with control values. Levels of alpha 1-antitrypsin (A 1-AT) showed marked season-related fluctuation patterns in Co children, the curves in E group children turned steeply upward from the third examination series on. Ceruloplasmin (CPL) levels in E group children had a clearcut upward trend at three subsequent blood samplings, the curves in Co group children continued to drop. Children from area E showed markedly higher frequency rates of abnormal values than did children from Co area.
选取了一群儿童作为半队列研究对象，这些儿童初始年龄约为11.5岁，来自一家二级铅冶炼厂附近的暴露区域（E组儿童），检测了他们血液和唾液中的一些体液免疫反应参数，并与一组年龄匹配、生活在相对无污染农村地区的对照儿童（Co组儿童）进行比较。在连续两年的时间里，每年春秋两季进行所有检查，最终分析纳入的数据仅来自完成了至少4次检查系列中的3次检查的儿童。总之，E区域的儿童平均血铅（Pb）水平明显升高，且有明显的季节性波动，在春季达到峰值；Co组儿童血液中的铅水平没有这种与季节相关的波动模式，并且在两年的观察期内有轻微下降趋势。E区域的δ-氨基乙酰丙酸脱水酶（ALAD）水平平均值明显低于Co区域，但未观察到与平均血铅水平的相关性。IgG水平在两性中或多或少与铅水平呈负相关，IgM水平在E组儿童的所有采样中均呈明显下降趋势。E区域儿童的总血清蛋白（SP）水平与铅血症呈负相关，分泌型IgA（sIgA）浓度在E组两性儿童中均降低，但这些值趋于与对照值接近。α1-抗胰蛋白酶（A1-AT）水平在Co组儿童中有明显的与季节相关的波动模式，E组儿童的曲线从第三次检查系列开始急剧上升。E组儿童的铜蓝蛋白（CPL）水平在随后的三次血液采样中有明显的上升趋势，Co组儿童的曲线则持续下降。E区域的儿童异常值出现频率明显高于Co区域的儿童。
