Departamento de Microbiologia, Universidad de Malaga, Spain.
Mar Pollut Bull. 2013 May 15;70(1-2):197-203. doi: 10.1016/j.marpolbul.2013.02.037. Epub 2013 Mar 19.
Marine bacteria exposed to antibiotics in fish farms can acquire antimicrobial resistance by mobile genetic elements and horizontal gene transfer. A total of 872 autochthonous marine bacterial strains was isolated from samples collected from four different fish farms located at northern and southern Italian Adriatic Sea. Resistance to only tetracycline (17%) and to trimethoprim-sulfadiazine (7%) were the most frequent patterns obtained, while flumequine resistance has recorded in only 0.3% of the strains. Comparing strains isolated from coastal areas and fish farms, a significant higher incidence (4% versus 10%) of multi-resistant strains in aquaculture centers was found. Significant differences in antibiotic resistance incidence were also detected among the four fish farms due probably to different approaches in farm management and the more or less frequent use of antibiotics. Antibiotic-resistant and multi-resistant strains isolated constitute an environmental reservoir directly involved in the seafood chain and might represent a public health concern.
养殖鱼类环境中的海洋细菌可通过移动遗传元件和水平基因转移获得抗生素耐药性。从意大利亚得里亚海北部和南部四个不同的养殖场采集样本，共分离到 872 株土著海洋细菌。获得的最常见的耐药模式是仅对四环素（17%）和甲氧苄啶-磺胺甲恶唑（7%）耐药，而氟喹诺酮类耐药的菌株仅占 0.3%。与从沿海地区和养殖场分离的菌株相比，在水产养殖中心发现了更高比例的多重耐药菌株（4%对 10%）。由于水产养殖管理方式的不同，以及抗生素的使用频率或多或少，四个养殖场之间也检测到了抗生素耐药性发生率的显著差异。分离出的耐药和多重耐药菌株直接构成了海鲜链中的环境储库，可能成为公共卫生关注的问题。
