Institut de Biologie Moléculaire des Plantes du CNRS; UPR2357; Université de Strasbourg; Strasbourg, France.
Plant Signal Behav. 2013 Jun;8(6):e24274. doi: 10.4161/psb.24274. Epub 2013 Mar 21.
The non-protein amino acid γ-aminobutyric acid (GABA) accumulates in plants in response to a wide variety of environmental cues. Recent data point toward an involvement of GABA in tricarboxylic acid (TCA) cycle activity and respiration, especially in stressed roots. To gain further insights into potential GABA functions in plants, phylogenetic and bioinformatic approaches were undertaken. Phylogenetic reconstruction of the GABA transaminase (GABA-T) protein family revealed the monophyletic nature of plant GABA-Ts. However, this analysis also pointed to the common origin of several plant aminotransferases families, which were found more similar to plant GABA-Ts than yeast and human GABA-Ts. A computational analysis of AtGABA-T co-expressed genes was performed in roots and in stress conditions. This second approach uncovered a strong connection between GABA metabolism and glyoxylate cycle during stress. Both in silico analyses open new perspectives and hypotheses for GABA metabolic functions in plants.
非蛋白氨基酸 γ-氨基丁酸（GABA）在植物中积累，以响应各种环境信号。最近的数据表明 GABA 参与三羧酸（TCA）循环活性和呼吸作用，特别是在应激根中。为了深入了解 GABA 在植物中的潜在功能，采用了系统发生和生物信息学方法。GABA 转氨酶（GABA-T）蛋白家族的系统发生重建揭示了植物 GABA-Ts 的单系性质。然而，该分析还指出了几种植物氨基转移酶家族的共同起源，这些家族与植物 GABA-Ts 比酵母和人类 GABA-Ts 更为相似。在根和胁迫条件下对 AtGABA-T 共表达基因进行了计算分析。第二种方法揭示了应激过程中 GABA 代谢与乙醛酸循环之间的紧密联系。这两种计算分析为 GABA 代谢功能在植物中的研究开辟了新的视角和假说。
