College of Medicine, King Faisal University, Alahsa 31982, PO Box 400, Kingdom of Saudi Arabia.
Department of Life Sciences, Faculty of Science and Technology, Anglia Ruskin University, East Road, Cambridge CB1 1PT, UK.
J Med Microbiol. 2013 Jun;62(Pt 6):885-888. doi: 10.1099/jmm.0.057216-0. Epub 2013 Mar 21.
Carbapenem-resistant Acinetobacter baumannii is becoming increasingly prevalent in patients with diabetes mellitus in the Middle East. We examined the relationship of these bacteria and their resistance mechanisms to the diabetic disease status of patients in Saudi Arabia. Susceptibilities of 271 isolates to carbapenems, tigecycline and colistin were determined, followed by detection of carbapenemase genes. A blaVIM gene was detected in ~95 % of isolates; blaOXA-23 and blaOXA-40 genes were also prevalent. Diabetic patients were significantly more likely to carry carbapenem-resistant isolates. Carbapenem-resistant A. baumannii is a serious problem in diabetic patients, and molecular detection of resistance mechanisms in these isolates is required.
耐碳青霉烯类鲍曼不动杆菌在中东地区的糖尿病患者中越来越普遍。我们研究了这些细菌及其耐药机制与沙特阿拉伯患者糖尿病疾病状态的关系。测定了 271 株分离株对碳青霉烯类、替加环素和黏菌素的敏感性，然后检测了碳青霉烯酶基因。约 95%的分离株中检测到 blaVIM 基因；blaOXA-23 和 blaOXA-40 基因也很常见。糖尿病患者携带耐碳青霉烯类分离株的可能性明显更高。耐碳青霉烯类鲍曼不动杆菌是糖尿病患者的严重问题，需要对这些分离株的耐药机制进行分子检测。
