阿昔莫司与烟酸治疗2b型高脂血症的比较。
A comparison of acipimox and nicotinic acid in type 2b hyperlipidaemia.
作者信息
O'Kane M J, Trinick T R, Tynan M B, Trimble E R, Nicholls D P
机构信息
Royal Victoria Hospital, Belfast, Northern Ireland.
出版信息
Br J Clin Pharmacol. 1992 Apr;33(4):451-3. doi: 10.1111/j.1365-2125.1992.tb04067.x.
The side effect profiles and lipid lowering efficacy of nicotinic acid (1 g three times daily) and its analogue acipimox (250 mg three times daily) in type 2b hyperlipidaemia were compared in a double-blind placebo controlled study. In the nicotinic acid group (n = 7) at 12 weeks there were significant reductions (P less than 0.05) with respect to placebo (n = 9) in total cholesterol (median and range) 6.6 mmol l-1 (4.8-8.4) vs 8.8 mmol l-1 (7.5-9.5), triglyceride 1.4 mmol l-1 (0.5-4.6) vs 2.8 mmol l-1 (1.5-9.5) and apoprotein B 88.6 mg dl-1 (62.1-114) vs 121.9 mg dl-1 (88.0-170.7). In contrast there was no significant alteration in lipids in the acipimox group (n = 12). Nicotinic acid was associated with a high incidence of side effects, principally cutaneous flushing, while acipimox was well tolerated by all patients.
在一项双盲安慰剂对照研究中，比较了烟酸（每日3次，每次1克）及其类似物阿西莫司（每日3次，每次250毫克）对2b型高脂血症的副作用情况和降脂疗效。在烟酸组（n = 7）中，12周时与安慰剂组（n = 9）相比，总胆固醇（中位数及范围）显著降低（P < 0.05），分别为6.6 mmol/L（4.8 - 8.4）和8.8 mmol/L（7.5 - 9.5）；甘油三酯分别为1.4 mmol/L（0.5 - 4.6）和2.8 mmol/L（1.5 - 9.5）；载脂蛋白B分别为88.6 mg/dl（62.1 - 114）和121.9 mg/dl（88.0 - 170.7）。相比之下，阿西莫司组（n = 12）的血脂没有显著变化。烟酸的副作用发生率较高，主要是皮肤潮红，而所有患者对阿西莫司的耐受性良好。
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