Serafini Fausta, Strati Francesco, Ruas-Madiedo Patricia, Turroni Francesca, Foroni Elena, Duranti Sabrina, Milano Francesco, Perotti Alessio, Viappiani Alice, Guglielmetti Simone, Buschini Annamaria, Margolles Abelardo, van Sinderen Douwe, Ventura Marco
Department of Genetics, Biology of Microorganisms, Anthropology and Evolution, University of Parma, Parma, Italy.
Anaerobe. 2013 Jun;21:9-17. doi: 10.1016/j.anaerobe.2013.03.003. Epub 2013 Mar 22.
Bifidobacteria are extensively exploited by the food industry as health-promoting microorganisms. However, very little is known about the molecular mechanisms responsible for these beneficial activities, or the molecular players that sustain their ability to colonize and persist within the human gut. Here, we have investigated the enteric adaptation features of the gut commensal Bifidobacterium bifidum PRL2010, originally isolated from infant feces. This strain was able to survive under gastrointestinal challenges, while it was shown to adhere to human epithelial intestinal cell monolayers (Caco 2 and HT-29), thereby inhibiting adhesion of pathogenic bacteria such as Escherichia coli and Cronobacter sakazakii.
双歧杆菌作为促进健康的微生物被食品工业广泛利用。然而，对于这些有益活动背后的分子机制，或者维持其在人类肠道内定殖和持续存在能力的分子因素，我们知之甚少。在此，我们研究了最初从婴儿粪便中分离出的肠道共生菌双歧双歧杆菌PRL2010的肠道适应特性。该菌株能够在胃肠道挑战下存活，同时被证明能黏附于人类肠上皮细胞单层（Caco 2和HT - 29），从而抑制诸如大肠杆菌和阪崎肠杆菌等病原菌的黏附。
