Turroni Francesca, Serafini Fausta, Mangifesta Marta, Arioli Stefania, Mora Diego, van Sinderen Douwe, Ventura Marco
Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland.
FEMS Microbiol Lett. 2014 Aug;357(1):23-33. doi: 10.1111/1574-6968.12509. Epub 2014 Jul 7.
Cell surface pili have recently been found in many different bifidobacterial species, including the infant gut commensal Bifidobacterium bifidum PRL2010. Pili produced by PRL2010 have been shown to be important molecular mediators for bacterial interaction with its human host. However, nothing is known about the modulation of their expression in response to cues that reflect the gastro intestinal environment, such as thermal, acidic, and osmotic challenges, or the presence of other gut microorganisms. Here, we investigated how different stress conditions that simulate the gastrointestinal niche influence the expression of PRL2010 sortase-dependent pili, and how this may impact on the coexistence and interaction with other human gut commensals.
最近在许多不同的双歧杆菌物种中发现了细胞表面菌毛，包括婴儿肠道共生菌两歧双歧杆菌PRL2010。PRL2010产生的菌毛已被证明是细菌与其人类宿主相互作用的重要分子介质。然而，对于其表达如何响应反映胃肠道环境的线索（如热、酸性和渗透压挑战，或其他肠道微生物的存在）的调节，我们一无所知。在这里，我们研究了模拟胃肠道生态位的不同应激条件如何影响PRL2010分选酶依赖性菌毛的表达，以及这可能如何影响与其他人类肠道共生菌的共存和相互作用。
