日本冲绳儿童中抗人类嗜T细胞病毒I型抗体血清转化的研究。

Study of seroconversion of antibody to human T-cell lymphotropic virus type-I in children of Okinawa, Japan.

作者信息

Kajiyama W, Kashiwagi S, Hayashi J, Nomura H, Ikematsu H, Noguchi A, Nakashima K, Okochi K

机构信息

Department of General Medicine, Faculty of Medicine, Kyushu University, Fukuoka.

出版信息

Microbiol Immunol. 1990;34(3):259-67. doi: 10.1111/j.1348-0421.1990.tb01008.x.

DOI:10.1111/j.1348-0421.1990.tb01008.x

PMID:2352497

Abstract

From 1983 to 1986, 1,813 children in nursery schools in Ishigaki Island and 1,228 children under 15 years old in the rural area in the Yaeyama District of Okinawa, Japan, were tested for anti-HTLV-I; 18 children (1.0%) in Ishigaki Island and 39 children (3.2%) in the rural area were positive. In order to survey when anti-HTLV-I developed in these children, their older serum samples were investigated retrospectively for 1 to 5 years. Two cases of seroconversion from anti-HTLV-I negative to positive were found between the age of 2 and 4, and there were no cases of seroconversion over 4 years old. Among the children who suffered maternal transmission of HTLV-I and developed anti-HTLV-I before the age of 15, about 80% of the children were considered to have anti-HTLV-I before the age of 2, and the remainder developed anti-HTLV-I before the age of 4.

摘要

1983年至1986年，对日本冲绳县八重山地区石垣岛托儿所的1813名儿童以及该地区农村1228名15岁以下儿童进行了抗人嗜T淋巴细胞病毒I型（anti-HTLV-I）检测；石垣岛有18名儿童（1.0%）呈阳性，农村地区有39名儿童（3.2%）呈阳性。为了调查这些儿童何时感染anti-HTLV-I，对他们1至5年前的血清样本进行了回顾性研究。发现2例在2至4岁之间抗HTLV-I从阴性转为阳性，4岁以上无血清转换病例。在15岁前通过母婴传播感染HTLV-I并产生抗HTLV-I的儿童中，约80%的儿童在2岁前就检测出抗HTLV-I，其余儿童在4岁前产生抗HTLV-I。