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浆细胞样树突状细胞在乳腺癌骨转移中的作用。

Role of plasmacytoid dendritic cells in breast cancer bone dissemination.

作者信息

Sawant Anandi, Ponnazhagan Selvarangan

机构信息

Department of Pathology; The University of Alabama at Birmingham; Birmingham, AL USA.

出版信息

Oncoimmunology. 2013 Feb 1;2(2):e22983. doi: 10.4161/onci.22983.

DOI:10.4161/onci.22983
PMID:23526329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3601166/
Abstract

Elevated levels of plasmacytoid dendritic cells (pDC) have been observed as breast cancer disseminates to the bone. The selective depletion of pDC in mice led to a total abrogation of bone metastasis as well as to an increase in T1 antitumor response, suggesting that pDC may be considered as a potential therapeutic target for metastatic breast cancer.

摘要

当乳腺癌扩散至骨骼时，已观察到浆细胞样树突状细胞（pDC）水平升高。小鼠体内pDC的选择性耗竭导致骨转移完全消除以及T1抗肿瘤反应增强，这表明pDC可被视为转移性乳腺癌的一个潜在治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef81/3601166/69e38281867e/onci-2-e22983-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef81/3601166/69e38281867e/onci-2-e22983-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef81/3601166/69e38281867e/onci-2-e22983-g1.jpg

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