Tian Saisai, Yan Li, Fu Lu, Zhang Zhen, Zhang Jinbo, Meng Guofeng, Zhang Weidong
School of Pharmacy, Second Military Medical University, Shanghai, China.
Department of Pharmacy, Tianjin Rehabilitation and Recuperation Center, Joint Logistics Support Force, Tianjin, China.
Front Cell Dev Biol. 2021 Apr 1;9:640476. doi: 10.3389/fcell.2021.640476. eCollection 2021.
Plasmacytoid dendritic cells (pDC) are an essential immune microenvironment component. They have been reported for crucial roles in linking the adaptive and immune systems. However, the prognostic role of the pDC in breast cancer (BRCA) was controversial. In this work, we collected large sample cohorts and did a comprehensive investigation to reveal the relationship between pDC and BRCA by multiomics data analysis. Elevated pDC levels were correlated with prolonged survival outcomes in BRCA patients. The distinct mutation landscape and lower burden of somatic copy number alterations (SCNA) and lower intratumoral heterogeneity were observed in the high pDC abundance group. Additionally, a more sensitive immune response and chemotherapies response were observed in the high pDC group, which implicates that patients with high pDC abundance can be benefited from the combination of chemotherapy and immunotherapy. In conclusion, the correlation between pDC abundance and BRCA patients' overall survival (OS) was found to be positive. We identified the molecular profiles of BRCA patients with pDC abundance. Our findings may be beneficial in aiding in the development of immunotherapy and elucidating on the precision treatment for BRCA.
浆细胞样树突状细胞（pDC）是免疫微环境的重要组成部分。据报道，它们在连接适应性免疫系统和固有免疫系统方面发挥着关键作用。然而，pDC在乳腺癌（BRCA）中的预后作用存在争议。在这项研究中，我们收集了大量样本队列，并通过多组学数据分析进行了全面调查，以揭示pDC与BRCA之间的关系。BRCA患者中pDC水平升高与生存结局延长相关。在高pDC丰度组中观察到独特的突变格局、较低的体细胞拷贝数改变（SCNA）负担和较低的肿瘤内异质性。此外，在高pDC组中观察到更敏感的免疫反应和化疗反应，这意味着高pDC丰度的患者可以从化疗和免疫治疗的联合应用中获益。总之，发现pDC丰度与BRCA患者的总生存期（OS）呈正相关。我们确定了具有pDC丰度的BRCA患者的分子特征。我们的研究结果可能有助于免疫治疗的发展，并阐明BRCA的精准治疗。
