Department of Immunology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Kraków, Poland.
PLoS One. 2013;8(3):e58709. doi: 10.1371/journal.pone.0058709. Epub 2013 Mar 20.
Chemerin, a chemoattractant ligand for chemokine-like receptor 1 (CMKLR1) is predicted to share similar tertiary structure with antibacterial cathelicidins. Recombinant chemerin has antimicrobial activity. Here we show that endogenous chemerin is abundant in human epidermis, and that inhibition of bacteria growth by exudates from organ cultures of primary human skin keratinocytes is largely chemerin-dependent. Using a panel of overlapping chemerin-derived synthetic peptides, we demonstrate that the antibacterial activity of chemerin is primarily mediated by Val(66)-Pro(85), which causes direct bacterial lysis. Therefore, chemerin is an antimicrobial agent in human skin.
趋化素（chemerin）是趋化素样受体 1（CMKLR1）的趋化配体，据预测其具有与抗菌 cathelicidins 相似的三级结构。重组趋化素具有抗菌活性。本文作者发现，内源性趋化素在人表皮中含量丰富，且原代人皮肤角质形成细胞器官培养物的分泌物可显著抑制细菌生长，这主要依赖于趋化素。通过一系列重叠的趋化素衍生合成肽，作者证明趋化素的抗菌活性主要由 Val(66)-Pro(85)介导，可直接导致细菌裂解。因此，趋化素是人类皮肤中的一种抗菌剂。
