Poiană Cătălina, Neamţu M C, Avramescu Elena Taina, Carşote Mara, Trifănescu Raluca, Terzea Dana, Neamţu Oana Maria, Dănciulescu Miulescu Rucsandra
"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Rom J Morphol Embryol. 2013;54(1):201-3.
Dedifferentiation is a process that may be found in metastasis from the neuroendocrine tumors. We present the case of a female within the seventh decade of life incidentally diagnosed with a mature teratoma with element of cartilages, bronchia, mucinous glands, and a poorly differentiated neuroendocrine carcinoma (Ki67 of 30%). After six months of chemotherapy and another six months of disease free interval, a metastasis of the great omentum was removed. The dedifferentiation was diagnosed based on much higher Ki67 (of 70%). The loss of estrogen receptor of 40% from the initial site to 3% into metastasis indicates an exclusive neuroendocrine aggressive pattern. The ovarian carcinoid is a rare situation, and metastasis to the great omentum with dedifferentiation is even seldom.
去分化是一种可能在神经内分泌肿瘤转移过程中出现的现象。我们报告了一例70岁左右的女性病例，该患者偶然被诊断出患有成熟畸胎瘤，其中包含软骨、支气管、黏液腺成分以及低分化神经内分泌癌（Ki67为30%）。经过6个月的化疗以及另外6个月的无病间期后，切除了大网膜转移灶。基于更高的Ki67（70%）诊断为去分化。雌激素受体从初始部位的40%降至转移灶的3%，表明存在一种独特的神经内分泌侵袭模式。卵巢类癌是一种罕见情况，伴有去分化的大网膜转移则更为少见。
