Jack C R, Bentley M D, Twomey C K, Zinsmeister A R
Department of Diagnostic Radiology, Mayo Clinic, Rochester, MN 55905.
Radiology. 1990 Jul;176(1):205-9. doi: 10.1148/radiology.176.1.2353093.
An experiment was designed to compare the accuracy and reproducibility of three different techniques for in vivo magnetic resonance (MR) imaging-based volume measurements of brain structures. These techniques were tracing, thresholding, and random marking. Anterior temporal lobe (ATL) and hippocampal formation (HF) volumes in 10 volunteers were measured from MR images, as were four cylinders of known volume. The upper limit of accuracy of in vivo volume measurements is estimated to be within 0.1 cm3 of true volume for the HF and 0.9 cm3 for the ATL with a combined tracing-thresholding technique. Intra- and interobserver variations were estimated from the pooled standard deviations of HF and ATL measurements. With the combined tracing-thresholding technique, the coefficient of variation for HF measurement was 1.9%; for the ATL measurement, it was 0.7%. The results indicate that MR-based volume measurements of these brain structures can be made with high precision and reproducibility.
设计了一项实验，以比较三种不同技术在基于体内磁共振（MR）成像的脑结构体积测量中的准确性和可重复性。这些技术分别是跟踪法、阈值法和随机标记法。从磁共振图像中测量了10名志愿者的颞叶前部（ATL）和海马结构（HF）的体积，以及四个已知体积的圆柱体的体积。采用跟踪-阈值联合技术，体内体积测量的准确性上限估计为HF的真实体积在0.1立方厘米以内，ATL的真实体积在0.9立方厘米以内。通过HF和ATL测量的合并标准差估计观察者内和观察者间的差异。采用跟踪-阈值联合技术，HF测量的变异系数为1.9%；ATL测量的变异系数为0.7%。结果表明，基于磁共振的这些脑结构体积测量可以高精度和可重复地进行。
