1型α2α3α胶原蛋白具有致关节炎性。
1 Alpha 2 alpha 3 alpha collagen is arthritogenic.
作者信息
Morgan K, Evans H B, Firth S A, Smith M N, Ayad S, Weiss J B, Lennox Holt P J
出版信息
Ann Rheum Dis. 1983 Dec;42(6):680-3. doi: 10.1136/ard.42.6.680.
Abstract
Native 1 alpha 2 alpha 3 alpha collagen (500 micrograms per rat) was both immunogenic and arthritogenic in Alderley Park rats (46% developed arthritis) but only immunogenic in Sprague-Dawley rats. Conversely, native type II collagen (500 micrograms per rat) was immunogenic and arthritogenic in both strains (64% arthritic in Alderley Park strain, 57% arthritic in Sprague-Dawley strain). The inflammatory polyarthritis induced by 1 alpha 2 alpha 3 alpha collagen was similar to that produced by native type II collagen in clinical appearance, time of onset, and histology. Antibodies raised to native bovine type II collagen cross-reacted with native 1 alpha 2 alpha 3 alpha collagen and vice versa. Thus the minor collagen component of cartilage, the 1 alpha 2 alpha 3 alpha collagen, as well as the major collagen component, type II collagen, are immunogenic and arthritogenic in the rat, with strain differences.
摘要
天然1α2α3α胶原蛋白（每只大鼠500微克）在奥尔德利公园大鼠中具有免疫原性和致关节炎性（46%发生关节炎），但在斯普拉格-道利大鼠中仅具有免疫原性。相反，天然II型胶原蛋白（每只大鼠500微克）在两种品系中均具有免疫原性和致关节炎性（奥尔德利公园品系中64%患关节炎，斯普拉格-道利品系中57%患关节炎）。由1α2α3α胶原蛋白诱导的炎性多关节炎在临床表现、发病时间和组织学方面与天然II型胶原蛋白所产生的相似。针对天然牛II型胶原蛋白产生的抗体与天然1α2α3α胶原蛋白发生交叉反应，反之亦然。因此，软骨的次要胶原蛋白成分1α2α3α胶原蛋白以及主要胶原蛋白成分II型胶原蛋白在大鼠中均具有免疫原性和致关节炎性，存在品系差异。
相似文献
1
1 Alpha 2 alpha 3 alpha collagen is arthritogenic.1型α2α3α胶原蛋白具有致关节炎性。
Ann Rheum Dis. 1983 Dec;42(6):680-3. doi: 10.1136/ard.42.6.680.
2
Immunity to type XI collagen in mice. Evidence that the alpha 3(XI) chain of type XI collagen and the alpha 1(II) chain of type II collagen share arthritogenic determinants and induce arthritis in DBA/1 mice.小鼠对XI型胶原蛋白的免疫反应。XI型胶原蛋白的α3(XI)链和II型胶原蛋白的α1(II)链具有共同的致关节炎决定簇并在DBA/1小鼠中诱发关节炎的证据。
J Immunol. 1991 Jun 15;146(12):4130-7.
3
Arthritogenicity of minor cartilage collagens (types IX and XI) in mice.小鼠中次要软骨胶原蛋白（IX型和XI型）的致关节炎性。
Arthritis Rheum. 1990 Jan;33(1):1-8. doi: 10.1002/art.1780330101.
4
Collagen-induced arthritis--use of the direct and indirect haemolytic plaque-assay to study the humoral response to collagen.胶原诱导性关节炎——使用直接和间接溶血空斑试验研究对胶原的体液免疫反应。
Clin Exp Rheumatol. 1985 Jul-Sep;3(3):229-36.
5
Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.大鼠天然II型胶原诱导性关节炎。I. 对胶原的发病率及体液反应
Ann Rheum Dis. 1980 Jun;39(3):285-90. doi: 10.1136/ard.39.3.285.
6
Native type II collagen--induced arthritis in the rat: the effect of complement depletion by cobra venom factor.天然II型胶原诱导的大鼠关节炎：眼镜蛇毒因子对补体的消耗作用。
Arthritis Rheum. 1981 Nov;24(11):1356-62. doi: 10.1002/art.1780241104.
7
Polyarthritis in MRL-lpr/lpr mice: mouse type II collagen is antigenic but not arthritogenic.MRL-lpr/lpr小鼠的多关节炎：小鼠Ⅱ型胶原具有抗原性但不致关节炎。
Autoimmunity. 1989;4(1-2):31-41. doi: 10.3109/08916938909034357.
8
Native type II collagen-induced arthritis in the rat. III. Relationship between the cellular immune response to native type II collagen and arthritis.大鼠天然II型胶原诱导性关节炎。III. 对天然II型胶原的细胞免疫反应与关节炎之间的关系。
Ann Rheum Dis. 1983 Jun;42(3):331-7. doi: 10.1136/ard.42.3.331.
9
10
Resistance to collagen-induced arthritis in rats and rhesus monkeys after immunization with attenuated type II collagen.
Eur J Immunol. 1993 Jul;23(7):1588-94. doi: 10.1002/eji.1830230729.
引用本文的文献
1
The minor collagens in articular cartilage.关节软骨中的次要胶原蛋白。
Protein Cell. 2017 Aug;8(8):560-572. doi: 10.1007/s13238-017-0377-7. Epub 2017 Feb 17.
2
The genetics of rheumatoid arthritis and the need for animal models to find and understand the underlying genes.类风湿关节炎的遗传学以及对用于发现和理解潜在基因的动物模型的需求。
Arthritis Res. 2001;3(2):87-97. doi: 10.1186/ar145. Epub 2000 Dec 20.
3
Aggrecan: A Target Molecule of Autoimmune Reactions.聚集蛋白聚糖：自身免疫反应的靶分子。
Pathol Oncol Res. 1996;2(4):219-228. doi: 10.1007/BF02904814.
4
Rheumatoid arthritis viewed using a headache paradigm.类风湿性关节炎——基于头痛范例的视角
Arthritis Res. 2000;2(3):169-71. doi: 10.1186/ar84. Epub 2000 Apr 6.
5
Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats.大鼠软骨寡聚基质蛋白（COMP）诱导的关节炎
Clin Exp Immunol. 1998 Dec;114(3):477-84. doi: 10.1046/j.1365-2249.1998.00739.x.
6
Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.鉴定佐剂油诱导性关节炎大鼠的易感性基因座。
Proc Natl Acad Sci U S A. 1998 May 26;95(11):6383-7. doi: 10.1073/pnas.95.11.6383.
7
Role of superantigens in experimental arthritis.超抗原在实验性关节炎中的作用。
Springer Semin Immunopathol. 1996;17(4):363-73. doi: 10.1007/BF01795134.
8
Humoral immune response against minor collagens type IX and XI in patients with cartilage graft resorption after reconstructive surgery.重建手术后软骨移植吸收患者针对IX型和XI型次要胶原蛋白的体液免疫反应。
Ann Rheum Dis. 1994 Apr;53(4):229-34. doi: 10.1136/ard.53.4.229.
9
Incidence of antibodies to native and denatured cartilage collagens (types II, IX, and XI) and to type I collagen in rheumatoid arthritis.类风湿关节炎中针对天然和变性软骨胶原蛋白（II型、IX型和XI型）以及I型胶原蛋白抗体的发生率。
Ann Rheum Dis. 1987 Dec;46(12):902-7. doi: 10.1136/ard.46.12.902.
10
Antibodies to type II and XI collagens: evidence for the formation of antigen specific as well as cross reacting antibodies in patients with rheumatoid arthritis.抗II型和XI型胶原蛋白抗体：类风湿性关节炎患者体内抗原特异性及交叉反应性抗体形成的证据。
Ann Rheum Dis. 1988 Dec;47(12):1008-13. doi: 10.1136/ard.47.12.1008.
本文引用的文献
1
A modified uronic acid carbazole reaction.一种改良的糖醛酸咔唑反应。
Anal Biochem. 1962 Oct;4:330-4. doi: 10.1016/0003-2697(62)90095-7.
2
Native type II collagen-induced arthritis in the rat. I. Incidence and humoral response to collagen.大鼠天然II型胶原诱导性关节炎。I. 对胶原的发病率及体液反应
Ann Rheum Dis. 1980 Jun;39(3):285-90. doi: 10.1136/ard.39.3.285.
3
Isolation and characterisation of an unusual collagen from hyaline cartilage and intervertebral disc.从透明软骨和椎间盘中分离并鉴定一种特殊的胶原蛋白。
FEBS Lett. 1981 Jan 26;123(2):195-9. doi: 10.1016/0014-5793(81)80286-4.
4
Characterisation of another short-chain disulphide-bonded collagen from cartilage, vitreous and intervertebral disc.软骨、玻璃体和椎间盘中另一种短链二硫键结合胶原蛋白的特性分析。
FEBS Lett. 1982 Mar 22;139(2):300-4. doi: 10.1016/0014-5793(82)80875-2.
5
Immunogenetic control of experimental type II collagen-induced arthritis. I. Susceptibility and resistance among inbred strains of rats.实验性II型胶原诱导性关节炎的免疫遗传控制。I. 近交系大鼠中的易感性和抗性
Arthritis Rheum. 1981 Jun;24(6):781-9. doi: 10.1002/art.1780240605.
6
Immunisation against heterologous type II collagen induces arthritis in mice.针对异源II型胶原蛋白进行免疫接种会在小鼠中诱发关节炎。
Nature. 1980 Feb 14;283(5748):666-8. doi: 10.1038/283666a0.
7
Autoimmunity to type II collagen an experimental model of arthritis.针对II型胶原蛋白的自身免疫反应——一种关节炎实验模型
J Exp Med. 1977 Sep 1;146(3):857-68. doi: 10.1084/jem.146.3.857.
8
Collagen-induced arthritis in rats. Evaluation of early immunologic events.大鼠胶原诱导性关节炎。早期免疫事件的评估。
Arthritis Rheum. 1979 Dec;22(12):1344-51. doi: 10.1002/art.1780221205.
9
Collagen heterogeneity in human cartilage: identification of several new collagen chains.人类软骨中的胶原蛋白异质性：几种新胶原蛋白链的鉴定。
Biochem Biophys Res Commun. 1979 Apr 27;87(4):1124-31. doi: 10.1016/s0006-291x(79)80024-8.
10
Solid-phase radioimmunoassay for the detection of antibodies to collagen.用于检测胶原蛋白抗体的固相放射免疫测定法。
J Immunol Methods. 1979 May 10;27(1):31-41. doi: 10.1016/0022-1759(79)90236-9.
Zotero 插件