1型α2α3α胶原蛋白具有致关节炎性。
1 Alpha 2 alpha 3 alpha collagen is arthritogenic.
作者信息
Morgan K, Evans H B, Firth S A, Smith M N, Ayad S, Weiss J B, Lennox Holt P J
出版信息
Ann Rheum Dis. 1983 Dec;42(6):680-3. doi: 10.1136/ard.42.6.680.
Abstract
Native 1 alpha 2 alpha 3 alpha collagen (500 micrograms per rat) was both immunogenic and arthritogenic in Alderley Park rats (46% developed arthritis) but only immunogenic in Sprague-Dawley rats. Conversely, native type II collagen (500 micrograms per rat) was immunogenic and arthritogenic in both strains (64% arthritic in Alderley Park strain, 57% arthritic in Sprague-Dawley strain). The inflammatory polyarthritis induced by 1 alpha 2 alpha 3 alpha collagen was similar to that produced by native type II collagen in clinical appearance, time of onset, and histology. Antibodies raised to native bovine type II collagen cross-reacted with native 1 alpha 2 alpha 3 alpha collagen and vice versa. Thus the minor collagen component of cartilage, the 1 alpha 2 alpha 3 alpha collagen, as well as the major collagen component, type II collagen, are immunogenic and arthritogenic in the rat, with strain differences.
摘要
天然1α2α3α胶原蛋白（每只大鼠500微克）在奥尔德利公园大鼠中具有免疫原性和致关节炎性（46%发生关节炎），但在斯普拉格-道利大鼠中仅具有免疫原性。相反，天然II型胶原蛋白（每只大鼠500微克）在两种品系中均具有免疫原性和致关节炎性（奥尔德利公园品系中64%患关节炎，斯普拉格-道利品系中57%患关节炎）。由1α2α3α胶原蛋白诱导的炎性多关节炎在临床表现、发病时间和组织学方面与天然II型胶原蛋白所产生的相似。针对天然牛II型胶原蛋白产生的抗体与天然1α2α3α胶原蛋白发生交叉反应，反之亦然。因此，软骨的次要胶原蛋白成分1α2α3α胶原蛋白以及主要胶原蛋白成分II型胶原蛋白在大鼠中均具有免疫原性和致关节炎性，存在品系差异。
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