Zouboulis C C
Klinik für Dermatologie, Venerologie und Allergologie/Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau-Roßlau.
Hautarzt. 2013 Apr;64(4):235-40. doi: 10.1007/s00105-012-2457-1.
Acne is the most common skin disease worldwide. Choosing the appropriate therapeutic regimens for the clinically diversified disease phenotypes require good knowledge of its pathophysiology. New concepts in this field have been developed in the last 15 years. Acne vulgaris is an inflammatory disorder in which androgens, PPAR ligands, regulating neuropeptides and environmental factors are probably involved as triggers. These factors interrupt the natural cycling process in the sebaceous gland follicle and support the transition of microcomedones to comedones and clinically inflammatory lesions. Proinflammatory lipids, chemokines and cytokines overtake the role of mediators for the further development of acne lesions. Bacterial antigens can potentate the inflammatory phenomena.
痤疮是全球最常见的皮肤病。为临床上多样化的疾病表型选择合适的治疗方案需要对其病理生理学有充分的了解。在过去15年里，该领域已形成了一些新的概念。寻常痤疮是一种炎症性疾病，雄激素、过氧化物酶体增殖物激活受体（PPAR）配体、调节神经肽和环境因素可能作为触发因素参与其中。这些因素会干扰皮脂腺毛囊的自然循环过程，并促使微粉刺转变为粉刺和临床上的炎性皮损。促炎脂质、趋化因子和细胞因子在痤疮皮损的进一步发展中起介质作用。细菌抗原可增强炎症现象。
