Sasahara M, Matsuo M, Kakizaki G, Aikawa T, Sato T, Uejima K, Yamada A, Saito M, Nakamura K
Shizugawa Public General Hospital.
Tohoku J Exp Med. 1990 Mar;160(3):251-75. doi: 10.1620/tjem.160.251.
To elucidate the effects of long term ethanol intake on the parotid gland, light and electron microscopic observations of the parotid glands from male Wistar rats that had been given 20% ethanol ad lib instead of water were carried out. The findings were compared with the changes in the pancreas previously reported (Kakizaki et al. 1987). The results were as follows: (1) Severe lesions involving lobular units of the parotid gland were found in three rats exposed to ethanol. (2) From the early stages of ethanol ingestion, the lateral interdigitations of acinar cells widened irregularly. In the striated ducts, basal enfoldings became also irregular and short, while the mitochondria (which were a slender rod shape and arranged parallel to the basal enfoldings in control rats) became swollen, developed a dark matrix, a decrease in the cristae, and showed random arrangement. (3) Later, both tortous proliferation of the intercalated ducts and destruction as well as irregular lamination of the basal lamina of the striated ducts were observed frequently. (4) The animals developing severe morphological changes in the pancreas following ethanol ingestion were different from the animals developing severe changes in the parotid gland.
为阐明长期摄入乙醇对腮腺的影响，对给予20%乙醇自由饮用而非水的雄性Wistar大鼠的腮腺进行了光镜和电镜观察。将这些结果与先前报道的胰腺变化（Kakizaki等人，1987年）进行比较。结果如下：（1）在三只接触乙醇的大鼠中发现了累及腮腺小叶单位的严重病变。（2）从乙醇摄入的早期阶段开始，腺泡细胞的侧向交错不规则增宽。在纹状管中，基底褶也变得不规则且变短，而线粒体（在对照大鼠中呈细长杆状并与基底褶平行排列）则肿胀，基质变暗，嵴减少，并呈随机排列。（3）后来，经常观察到闰管的迂曲增生以及纹状管基底膜的破坏和不规则分层。（4）摄入乙醇后胰腺发生严重形态变化的动物与腮腺发生严重变化的动物不同。
