Runco Lisa M, Coleman J Robert
New York Institute of Technology (NYIT), Department of Life Sciences, Old Westbury, NY 11568-8000, USA.
J Pathog. 2011;2011:765763. doi: 10.4061/2011/765763. Epub 2011 Mar 16.
Given the interconnected nature of our world today, emerging pathogens and pandemic outbreaks are an ever-growing threat to the health and economic stability of the global community. This is evident by the recent 2009 Influenza A (H1N1) pandemic, the SARS outbreak, as well as the ever-present threat of global bioterrorism. Fortunately, the biomedical community has been able to rapidly generate sequence data so these pathogens can be readily identified. To date, however, the utilization of this sequence data to rapidly produce relevant experimental results or actionable treatments is lagging in spite of obtained sequence data. Thus, a pathogenic threat that has emerged and/or developed into a pandemic can be rapidly identified; however, translating this identification into a targeted therapeutic or treatment that is rapidly available has not yet materialized. This commentary suggests that the growing technology of DNA synthesis should be fully implemented as a means to rapidly generate in vivo data and possibly actionable therapeutics soon after sequence data becomes available.
鉴于当今世界的相互联系，新出现的病原体和大流行疫情对全球社区的健康和经济稳定构成了日益严重的威胁。2009年甲型H1N1流感大流行、非典疫情以及全球生物恐怖主义的持续威胁都证明了这一点。幸运的是，生物医学界能够迅速生成序列数据，以便能够轻松识别这些病原体。然而，尽管已经获得了序列数据，但利用这些序列数据迅速产生相关实验结果或可行治疗方法的工作目前仍滞后。因此，已经出现和/或发展成为大流行的致病威胁能够迅速被识别；然而，将这种识别转化为迅速可用的靶向治疗方法尚未实现。本评论认为，应充分利用日益发展的DNA合成技术，以便在序列数据可用后迅速生成体内数据并可能产生可行的治疗方法。
