Shirzadi Ali S, Drazin Doniel G, Strickland Allison S, Bannykh Serguei I, Johnson J Patrick
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Case Rep Surg. 2013;2013:107315. doi: 10.1155/2013/107315. Epub 2013 Feb 19.
Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. We report a case of ENB with multiple drop metastases to the cervical and thoracic spine, and review the patient's disease, medical history, and multiple interventions during a span of 15 years following the initial cranial resection. Despite aggressive multiple surgical resections, radiation, and chemotherapy, the tumor had significant progression and recurrence. The literature is reviewed, followed by a discussion of the natural progression of the disease and various reported interventions. Although a combination of surgery with chemotherapy and radiation therapy has been recommended, no definitive management has been established for ENB. Further research is needed to determine decisive treatment for metastatic ENB to the spine.
嗅神经母细胞瘤（ENB）是一种罕见的侵袭性鼻腔恶性肿瘤，起源于嗅上皮的神经嵴细胞。虽然局部侵犯鼻窦很常见，但ENB的脊柱转移很少见，仅有28例记录在案的病例累及脊柱、脊髓或软脑膜。我们报告1例发生颈椎和胸椎多处播散性转移的ENB病例，并回顾患者自首次颅骨切除术后15年期间的病情、病史及多次干预情况。尽管进行了积极的多次手术切除、放疗和化疗，肿瘤仍有显著进展和复发。本文回顾了相关文献，随后讨论了该疾病的自然病程及各种已报道的干预措施。虽然推荐手术联合化疗和放疗，但尚未确立针对ENB的确切治疗方案。需要进一步研究以确定转移性ENB至脊柱的决定性治疗方法。
