Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon 97239, USA.
J Neurosurg Spine. 2011 Nov;15(5):571-5. doi: 10.3171/2011.6.SPINE11157. Epub 2011 Jul 29.
Esthesioneuroblastoma is an aggressive neuroectodermal tumor that originates from the olfactory mucosa and often recurs locally. Distant metastasis of esthesioneuroblastoma has been described, but there are few reports of drop metastasis to the spinal cord. Here, we report a case of multiple drop metastases to the cervical, thoracic, and lumbar regions of the spinal cord that occurred 18 years after resection and radiotherapy of the original anterior cranial fossa lesion. There was no evidence of local recurrence. The symptomatic lesion was treated with resection and adjuvant chemotherapy. The options available for treatment of this disease are summarized with a review of the few reported cases of spinal metastasis of esthesioneuroblastoma.
嗅神经母细胞瘤是一种源自嗅黏膜的侵袭性神经外胚层肿瘤，常局部复发。嗅神经母细胞瘤已被描述发生远处转移，但鲜有脊髓种植性转移的报道。在此，我们报告 18 年前前颅窝病变切除和放疗后，发生于颈、胸、腰多个脊髓节段的多发性种植性转移病例。无局部复发证据。症状性病变行切除和辅助化疗。总结了此类疾病的治疗选择，并复习了少数嗅神经母细胞瘤脊髓转移的报道病例。
