Rudichenko V M
Lik Sprava. 2012 Jul-Sep(5):44-57.
In this article there were analyzed gender data about features of hyperuricaemia and gout: women are much older at the onset of gout arthritis (one of main reasons, probably, makes menopause by itself), have more associated comorbid deseases as hypertension and kidney failure and drinks less alcoholic beverages. It was noticed, that typical localisation of the lesion on the first toe is less often in women, and women are more inclined to use diuretics among medical drugs. Abovementioned clinical features are of some importance for the broad activity of general practitioners - family doctors. Gender features of polyarthicular gout are not uniformed. Scientific researches confirmed possibility of the genetic basis of the uric acid metabolism, which influences some fenotypical features of the organism. Several genes are known for their influence on serum uric acid: PDZK1, GCKR, SLC2A9, ABCG2, LRRC16A, SLC17A3, SLC16A9 and SLC22A12. However, conclusions of the research works confirm the necessity of scientific clarification of the importance of different factors of gender differences.
女性痛风性关节炎发病时年龄大得多（这可能是主要原因之一，本身就与绝经有关），患有更多的合并症，如高血压和肾衰竭，且饮用酒精饮料较少。人们注意到，女性较少出现典型的第一跖趾关节病变，且在药物治疗中更倾向于使用利尿剂。上述临床特征对全科医生（家庭医生）的广泛工作具有一定重要性。多关节痛风的性别特征并不一致。科学研究证实了尿酸代谢存在遗传基础的可能性，这会影响机体的一些表型特征。已知有几个基因会影响血清尿酸：PDZK1、GCKR、SLC2A9、ABCG2、LRRC16A、SLC17A3、SLC16A9和SLC22A12。然而，研究工作的结论证实有必要科学阐明不同性别差异因素的重要性。
