Department of Periodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Ren Fail. 2013;35(5):711-7. doi: 10.3109/0886022X.2013.777890. Epub 2013 Mar 28.
C-reactive protein (CRP) has been implicated as a possible mediator of the association between periodontitis and several systemic diseases. This study evaluated the impact of nonsurgical periodontal treatment on the serum levels of CRP in chronic kidney disease (CKD) patients on hemodialysis.
A total of 77 CKD patients on hemodialysis were included in this study. At baseline, periodontal examination was assessed for all the patients, and chronic periodontitis was defined through clinical attachment level and probing pocket depth, according to the American Association of Periodontology. Nonsurgical periodontal treatment was performed and serum levels of CRP were evaluated at baseline and 8 weeks after periodontal treatment.
Periodontal treatment resulted in significant reductions in CRP levels (p < 0.001). The difference between pre- and posttreatment CRP concentrations did not show any significant relationship with the severity of periodontitis.
Periodontitis is an important source of systemic inflammation in CKD patients. Nonsurgical periodontal treatment can effectively reduce the serum level of CRP in these patients.
C 反应蛋白（CRP）被认为是牙周炎与几种全身性疾病之间关联的一个可能的中介物。本研究评估了非手术牙周治疗对血液透析慢性肾脏病（CKD）患者血清 CRP 水平的影响。
本研究共纳入 77 名血液透析的 CKD 患者。在基线时，对所有患者进行牙周检查，并根据美国牙周病学会的标准，通过临床附着丧失和探诊牙周袋深度来定义慢性牙周炎。进行非手术牙周治疗，并在牙周治疗前和治疗后 8 周评估 CRP 血清水平。
牙周治疗导致 CRP 水平显著降低（p < 0.001）。治疗前后 CRP 浓度的差异与牙周炎的严重程度无显著关系。
牙周炎是 CKD 患者全身炎症的一个重要来源。非手术牙周治疗可有效降低这些患者的血清 CRP 水平。
