Department of Chemistry, Michigan State University, East Lansing, Michigan 48824-1322, USA.
J Am Chem Soc. 2013 May 22;135(20):7572-82. doi: 10.1021/ja400295v. Epub 2013 May 9.
With the aid of high-throughput screening, the efficiency of Ir-catalyzed C-H borylations has been assessed as functions of precatalyst, boron reagent, ligand, order of addition, temperature, solvent, and substrate. This study not only validated some accepted practices but also uncovered unconventional conditions that were key to substrate performance. We anticipate that insights drawn from these findings will be used to design reaction conditions for substrates whose borylations are difficult to impossible using standard catalytic conditions.
借助高通量筛选，评估了铱催化的 C-H 硼化反应的效率作为前催化剂、硼试剂、配体、添加顺序、温度、溶剂和底物的函数。这项研究不仅验证了一些公认的做法，还发现了一些非常规条件，这些条件是底物性能的关键。我们预计，从这些发现中获得的见解将用于设计反应条件，对于那些使用标准催化条件难以或不可能进行硼化的底物。
