Dai Zhi-Jun, Wu Wen-Ying, Kang Hua-Feng, Ma Xiao-Bin, Zhang Shu-Qun, Min Wei-Li, Kang Wang-Feng, Ma Xiao-Bin, Zhang Shu-Qun, Min Wei-Li, Lu Wang-Feng, Lin Shuai, Wang Xi-Jing
Department of Oncology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Asian Pac J Cancer Prev. 2013;14(1):261-5. doi: 10.7314/apjcp.2013.14.1.261.
Scutellaria barbata D. Don (S. barbata), a traditional Chinese medicine, is used to treat cancers, inflammation, and urinary diseases. This study aimed to determine any protective effects of S. barbata crude extract (CE-SB) against rat liver tumorigenesis induced by diethylnitrosamine (DENA). Liver malfunction indices in serum were measured by biochemical examination. Hematoxylin and eosin staining was performed to examine liver pathology. Contents of malondialdehyde (MDA) and superoxide dismutase (SOD) were measured in liver homogenates to evaluate oxidative stress. The levels of liver malfunction indices in the CE-SB groups, especially in the CE-SB high dose group, were lower than that of the model group (P<0.05). The results from histological examination indicated that the number of liver nodules in the CE-SB groups decreased compared with the model group (P<0.05). Content of MDA determined in liver was significantly decreased, and level of SOD elevated by CE-SB. CE-SB can inhibit experimental liver tumorigenesis and relieve hepatic injury in rats.
半枝莲，一种传统中药，用于治疗癌症、炎症和泌尿系统疾病。本研究旨在确定半枝莲粗提物（CE-SB）对二乙基亚硝胺（DENA）诱导的大鼠肝肿瘤发生是否具有保护作用。通过生化检查测定血清中的肝功能指标。进行苏木精-伊红染色以检查肝脏病理学。测定肝匀浆中丙二醛（MDA）和超氧化物歧化酶（SOD）的含量以评估氧化应激。CE-SB组，尤其是CE-SB高剂量组的肝功能指标水平低于模型组（P<0.05）。组织学检查结果表明，CE-SB组的肝结节数量与模型组相比减少（P<0.05）。CE-SB可使肝脏中测定的MDA含量显著降低，SOD水平升高。CE-SB可抑制大鼠实验性肝肿瘤发生并减轻肝损伤。
