Kahn Marc J, Maley Jason H, Lasker George F, Kadowitz Philip J
Department of Medicine, Section of Hematology/Medical Oncology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Cardiovasc Hematol Disord Drug Targets. 2013 Mar 1;13(1):83-7. doi: 10.2174/1871529x11313010009.
Nitric oxide is a potent vasodilator that plays a critical role in disorders of erythrocyte function. Sickle cell disease, paroxysmal nocturnal hemoglobinuria and banked blood preservation are three conditions where nitric oxide is intimately related to dysfunctional erythrocytes. These conditions are accompanied by hemolysis, thrombosis and vasoocclusion. Our understanding of the interaction between nitric oxide, hemoglobin, and the vasculature is constantly evolving, and by defining this role we can better direct trials aimed at improving the treatments of disorders of erythrocyte function. Here we briefly discuss nitric oxide's interaction with hemoglobin through the hypothesis regarding Snitrosohemoglobin, deoxyhemoglobin, and myoglobin as nitrite reductases. We then review the current understanding of the role of nitric oxide in sickle cell disease, paroxysmal nocturnal hemoglobinuria, and banked blood, and discuss therapeutics in development to target nitric oxide in the treatment of some of these disorders.
一氧化氮是一种强效血管舒张剂，在红细胞功能紊乱中起关键作用。镰状细胞病、阵发性夜间血红蛋白尿症和库存血保存是一氧化氮与功能失调红细胞密切相关的三种情况。这些情况伴有溶血、血栓形成和血管阻塞。我们对一氧化氮、血红蛋白和脉管系统之间相互作用的理解在不断发展，通过明确这一作用，我们可以更好地指导旨在改善红细胞功能紊乱治疗的试验。在此，我们通过关于亚硝基血红蛋白、脱氧血红蛋白和肌红蛋白作为亚硝酸盐还原酶的假说，简要讨论一氧化氮与血红蛋白的相互作用。然后，我们回顾了目前对一氧化氮在镰状细胞病、阵发性夜间血红蛋白尿症和库存血中的作用的理解，并讨论了正在开发的针对一氧化氮治疗其中一些疾病的疗法。
