开发一种（11）C 标记的四嗪用于快速四嗪-反式环辛烯连接。
Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation.
机构信息
Center for Integrated Molecular Brain Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
出版信息
Chem Commun (Camb). 2013 May 8;49(36):3805-7. doi: 10.1039/c3cc41027g. Epub 2013 Mar 27.
PMID:23535705
Abstract
Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.
摘要
四嗪-反式环辛烯键合反应非常快速且具有选择性，即使在低微摩尔浓度下也是如此。在生物正交放射化学中，能够将放射性探针与预靶向载体连接的工具非常重要。在此，我们成功开发了第一个（11）C 标记的四嗪，并研究了其与反式环辛烯醇的反应。
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