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COGS 研究的推进与激素介导的癌症研究有关。

Turning of COGS moves forward findings for hormonally mediated cancers.

机构信息

Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

出版信息

Nat Genet. 2013 Apr;45(4):345-8. doi: 10.1038/ng.2587.

DOI:10.1038/ng.2587
PMID:23535722
Abstract

The large-scale Collaborative Oncological Gene-environment Study (COGS) presents new findings that further characterize the genetic bases of breast, ovarian and prostate cancers. We summarize and provide insights into this collection of papers from COGS and discuss the implications of the results and future directions for such efforts.

摘要

大规模合作肿瘤基因-环境研究(COGS)提出了新的发现,进一步描述了乳腺癌、卵巢癌和前列腺癌的遗传基础。我们总结了 COGS 的这些论文,并讨论了这些结果的意义和未来的研究方向。

相似文献

1
Turning of COGS moves forward findings for hormonally mediated cancers.COGS 研究的推进与激素介导的癌症研究有关。
Nat Genet. 2013 Apr;45(4):345-8. doi: 10.1038/ng.2587.
2
iCOGS collection provides a collaborative model. Foreword.国际乳腺癌协会联盟(iCOGS)基因分型项目提供了一种合作模式。前言。
Nat Genet. 2013 Apr;45(4):343. doi: 10.1038/ng.2592.
3
Public health implications from COGS and potential for risk stratification and screening.从 COGS 角度看公共卫生影响,以及风险分层和筛查的可能性。
Nat Genet. 2013 Apr;45(4):349-51. doi: 10.1038/ng.2582.
4
Molecular basis for hormone-related cancer.
Lancet. 1993 Jun 26;341(8861):1630. doi: 10.1016/0140-6736(93)90767-b.
5
Prostate, Breast and Ovarian Cancer Genetic Risk Assessment: Connecting the Dots.
Can J Urol. 2016 Oct;23(5):8429.
6
The relationship between dairy consumption and the hormonally sensitive tumors of the prostate and breast: have the answers been found?
J S C Med Assoc. 2010 Feb;106(1):16-9.
7
BRCA1 and prostate cancer.乳腺癌1号基因(BRCA1)与前列腺癌
Cancer Invest. 2001;19(4):396-412. doi: 10.1081/cnv-100103134.
8
Risk of cancer at sites other than the breast in Swedish families eligible for BRCA1 or BRCA2 mutation testing.符合BRCA1或BRCA2基因突变检测条件的瑞典家族中,除乳腺外其他部位患癌的风险。
Ann Oncol. 2004 Dec;15(12):1834-41. doi: 10.1093/annonc/mdh474.
9
Update Swiss guideline for counselling and testing for predisposition to breast, ovarian, pancreatic and prostate cancer.更新瑞士乳腺癌、卵巢癌、胰腺癌和前列腺癌易感性咨询和检测指南。
Swiss Med Wkly. 2021 Sep 13;151:w30038. doi: 10.4414/SMW.2021.w30038.
10
Aggregation of ovarian cancer with breast, ovarian, colorectal, and prostate cancer in first-degree relatives.卵巢癌与一级亲属中的乳腺癌、卵巢癌、结直肠癌和前列腺癌的聚集性。
Am J Epidemiol. 2004 Apr 15;159(8):750-8. doi: 10.1093/aje/kwh103.

引用本文的文献

1
International strategy in cancer epidemiology: Japan's involvement in global projects and future role.癌症流行病学中的国际战略:日本在全球项目中的参与及未来作用。
Glob Health Med. 2021 Aug 31;3(4):187-195. doi: 10.35772/ghm.2021.01002.
2
Role of Sex in the Therapeutic Targeting of p53 Circuitry.性别在p53信号通路治疗靶点中的作用。
Front Oncol. 2021 Jul 8;11:698946. doi: 10.3389/fonc.2021.698946. eCollection 2021.
3
Boosting GWAS using biological networks: A study on susceptibility to familial breast cancer.利用生物网络增强全基因组关联研究:一项关于家族性乳腺癌易感性的研究

本文引用的文献

1
Evidence of gene-environment interactions between common breast cancer susceptibility loci and established environmental risk factors.常见乳腺癌易感基因座与已确定环境风险因素之间的基因-环境相互作用的证据。
PLoS Genet. 2013;9(3):e1003284. doi: 10.1371/journal.pgen.1003284. Epub 2013 Mar 27.
2
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.BRCA1 突变携带者的全基因组关联研究确定了与乳腺癌和卵巢癌风险相关的新位点。
PLoS Genet. 2013;9(3):e1003212. doi: 10.1371/journal.pgen.1003212. Epub 2013 Mar 27.
3
Identification of a BRCA2-specific modifier locus at 6p24 related to breast cancer risk.
PLoS Comput Biol. 2021 Mar 18;17(3):e1008819. doi: 10.1371/journal.pcbi.1008819. eCollection 2021 Mar.
4
Pleiotropic genetic influence on birth weight and childhood obesity.出生体重与儿童肥胖的多效遗传影响。
Sci Rep. 2021 Jan 8;11(1):48. doi: 10.1038/s41598-020-80084-9.
5
Performance of Breast Cancer Polygenic Risk Scores in 760 Female CHEK2 Germline Mutation Carriers.760 名 CHEK2 种系突变女性携带者的乳腺癌多基因风险评分表现。
J Natl Cancer Inst. 2021 Jul 1;113(7):893-899. doi: 10.1093/jnci/djaa203.
6
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges.靶向MDMX用于癌症治疗:原理、策略与挑战
Front Oncol. 2020 Aug 5;10:1389. doi: 10.3389/fonc.2020.01389. eCollection 2020.
7
Manipulating the Mouse Genome Using Recombineering.利用重组工程技术操控小鼠基因组
Adv Genet Eng. 2013;2(2). doi: 10.4172/2169-0111.1000108. Epub 2013 Jun 27.
8
Shared heritability and functional enrichment across six solid cancers.六种实体瘤的共享遗传率和功能富集。
Nat Commun. 2019 Jan 25;10(1):431. doi: 10.1038/s41467-018-08054-4.
9
Cancer genetics, precision prevention and a call to action.癌症遗传学、精准预防与行动呼吁。
Nat Genet. 2018 Sep;50(9):1212-1218. doi: 10.1038/s41588-018-0202-0. Epub 2018 Aug 29.
10
rs495139 in the TYMS-ENOSF1 Region and Risk of Ovarian Carcinoma of Mucinous Histology.TYMS-ENOSF1 区域内 rs495139 与黏液性卵巢癌风险的相关性
Int J Mol Sci. 2018 Aug 21;19(9):2473. doi: 10.3390/ijms19092473.
鉴定与乳腺癌风险相关的位于 6p24 的 BRCA2 特异性修饰基因座。
PLoS Genet. 2013;9(3):e1003173. doi: 10.1371/journal.pgen.1003173. Epub 2013 Mar 27.
4
Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers.11q13 乳腺癌风险位点的功能变体通过长距离增强子调控细胞周期蛋白 D1 的表达。
Am J Hum Genet. 2013 Apr 4;92(4):489-503. doi: 10.1016/j.ajhg.2013.01.002. Epub 2013 Mar 27.
5
Genome-wide association studies identify four ER negative-specific breast cancer risk loci.全基因组关联研究确定了四个 ER 阴性特异性乳腺癌风险位点。
Nat Genet. 2013 Apr;45(4):392-8, 398e1-2. doi: 10.1038/ng.2561.
6
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.利用 iCOGS 定制基因分型阵列鉴定 23 个新的前列腺癌易感性位点。
Nat Genet. 2013 Apr;45(4):385-91, 391e1-2. doi: 10.1038/ng.2560.
7
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.多个位于 TERT 基因座的独立变体与端粒长度和乳腺癌及卵巢癌的风险相关。
Nat Genet. 2013 Apr;45(4):371-84, 384e1-2. doi: 10.1038/ng.2566.
8
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.GWAS 荟萃分析和复制确定了三个新的卵巢癌易感性位点。
Nat Genet. 2013 Apr;45(4):362-70, 370e1-2. doi: 10.1038/ng.2564.
9
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.大规模基因分型鉴定出 41 个与乳腺癌风险相关的新位点。
Nat Genet. 2013 Apr;45(4):353-61, 361e1-2. doi: 10.1038/ng.2563.
10
Genome-wide association study of glioma and meta-analysis.全基因组关联研究与荟萃分析在脑胶质瘤中的应用
Hum Genet. 2012 Dec;131(12):1877-88. doi: 10.1007/s00439-012-1212-0. Epub 2012 Aug 11.