将 5-脱氧-5-[18F]氟代核糖标记肽的概念转化为临床前实践：用于炎症 PET 成像的 Siglec-9 肽的 18F 标记。
Translating the concept of peptide labeling with 5-deoxy-5-[18F]fluororibose into preclinical practice: 18F-labeling of Siglec-9 peptide for PET imaging of inflammation.
机构信息
Department of Pharmacology, Drug Development and Therapeutics, University of Turku, FI-20014 Turku, Finland.
Turku PET Centre, University of Turku and Turku University Hospital, FI-20521 Turku, Finland.
出版信息
Chem Commun (Camb). 2013 May 7;49(35):3682-3684. doi: 10.1039/c3cc40738a. Epub 2013 Mar 27.
PMID:23536117
Abstract
Peptide glycosylation with 5-deoxy-5-[(18)F]fluororibose was translated into preclinical settings. The novel (18)F-labeled Siglec-9 peptide was produced using an automated synthesis procedure. The (18)F-labeled Siglec-9 peptide showed favorable binding in the animal model of inflammation in vivo.
摘要
肽的 5-脱氧-5-[(18)F]氟核糖基糖基化被转化到了临床前环境中。新型（18）F 标记的 Siglec-9 肽是使用自动化合成程序生产的。（18）F 标记的 Siglec-9 肽在炎症的动物模型中表现出了有利的结合。
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