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用于光动力疗法的新型Bodipy敏化剂的脂质体包封研究。

Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy.

作者信息

Gayathri Thumuganti, Vijayalakshmi A, Mangalath Sreejith, Joseph Joshy, Rao N Madhusudhana, Singh Surya Prakash

机构信息

Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Uppal road, Tarnaka, Hyderabad-500007, India.

Academy of Scientific and Innovative Research, Uttar Pradesh-201002, India.

出版信息

ACS Med Chem Lett. 2018 Feb 4;9(4):323-327. doi: 10.1021/acsmedchemlett.7b00490. eCollection 2018 Apr 12.

DOI:10.1021/acsmedchemlett.7b00490
PMID:29670694
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5900332/
Abstract

We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV-3). The IC values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC = 0.39 μM) under similar experimental conditions.

摘要

我们报道了一系列基于Bodipy核心的用于光动力疗法（PDT）的四种高效光敏剂（PSs）。在没有亲水性官能团的情况下，这些PSs已被包裹在脂质体中，并检测了其对人卵巢癌细胞系（SK-OV-3）的光细胞毒性。获得的IC值低至0.350μM，在相似实验条件下可与经典光敏剂氯e6（IC = 0.39μM）相媲美。