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2
Assessment of the optimal cutoff value of fasting plasma glucose to establish diagnosis of gestational diabetes mellitus in Chinese women.评估空腹血浆葡萄糖的最佳截断值以建立中国女性妊娠期糖尿病的诊断标准。
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Utility of Pregestational Body Mass Index and Initial Fasting Plasma Glucose in Predicting Gestational Diabetes Mellitus.孕前体重指数和初始空腹血糖在预测妊娠期糖尿病中的效用。
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Fasting plasma glucose and risk factor assessment: Comparing sensitivity and specificity in identifying gestational diabetes in urban black African women.空腹血糖和危险因素评估：比较在识别城市黑非裔妇女妊娠期糖尿病中的敏感性和特异性。
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Gestational diabetes mellitus: simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucose.妊娠期糖尿病：使用空腹血糖简化国际糖尿病与妊娠研究组诊断算法。
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Fasting plasma glucose as a screening test for gestational diabetes in a multi-ethnic, high-risk population.空腹血糖作为多民族高危人群妊娠期糖尿病的筛查试验。
Diabet Med. 2000 Oct;17(10):720-6. doi: 10.1046/j.1464-5491.2000.00371.x.
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Association between the cut-off value of the first trimester fasting plasma glucose level and gestational diabetes mellitus: a retrospective study from southern China.早孕期空腹血糖水平截断值与妊娠期糖尿病的关系：来自中国南方的回顾性研究。
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Can J Diabetes. 2018 Oct;42(5):500-504. doi: 10.1016/j.jcjd.2017.12.009. Epub 2017 Dec 15.

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Response to "Fasting plasma glucose level to guide the need for an OGTT to screen for gestational diabetes mellitus".对“空腹血糖水平指导进行口服葡萄糖耐量试验以筛查妊娠期糖尿病的必要性”的回应
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What is the "cost" of reducing adverse pregnancy outcomes in patients with gestational diabetes mellitus - risk factors for perinatal complications in a retrospective cohort of pregnant women with GDM.降低妊娠期糖尿病患者不良妊娠结局的“代价”——回顾性队列研究中 GDM 孕妇围产期并发症的风险因素。
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The role of first-trimester HbA1c in the early detection of gestational diabetes.早孕期 HbA1c 在妊娠期糖尿病早期检测中的作用。
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Dietary cholesterol and egg intake are associated with the risk of gestational diabetes: a prospective study from Southwest China.膳食胆固醇和鸡蛋摄入量与妊娠期糖尿病的风险相关：来自中国西南部的前瞻性研究。
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Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM.循环外泌体 hsa_circRNA_0039480 在妊娠期糖尿病中高表达，可作为 GDM 早期诊断的生物标志物。
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本文引用的文献

1
Diagnostic criteria for gestational diabetes mellitus (WS 331-2011).妊娠期糖尿病诊断标准（WS 331-2011）。
Chin Med J (Engl). 2012 Apr;125(7):1212-3.
2
Gestational diabetes screening: the low-cost algorithm.妊娠期糖尿病筛查：低成本算法。
Int J Gynaecol Obstet. 2011 Nov;115 Suppl 1:S30-3. doi: 10.1016/S0020-7292(11)60009-X.
3
The risk of overt diabetes mellitus among women with gestational diabetes: a population-based study.妊娠期糖尿病女性发生显性糖尿病的风险：一项基于人群的研究。
Diabet Med. 2010 Jul;27(7):779-85. doi: 10.1111/j.1464-5491.2010.02995.x.
4
Gestational diabetes: risk of recurrence in subsequent pregnancies.妊娠糖尿病：再次妊娠的复发风险。
Am J Obstet Gynecol. 2010 Nov;203(5):467.e1-6. doi: 10.1016/j.ajog.2010.05.032. Epub 2010 Jul 13.
5
Gestational diabetes mellitus: simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucose.妊娠期糖尿病：使用空腹血糖简化国际糖尿病与妊娠研究组诊断算法。
Diabetes Care. 2010 Sep;33(9):2018-20. doi: 10.2337/dc10-0572. Epub 2010 Jun 2.
6
International association of diabetes and pregnancy study groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy.国际糖尿病与妊娠研究组协会关于妊娠期间高血糖的诊断和分类的建议
Diabetes Care. 2010 Mar;33(3):676-82. doi: 10.2337/dc09-1848.
7
Hormonal and metabolic factors associated with variations in insulin sensitivity in human pregnancy.与人类妊娠期间胰岛素敏感性变化相关的激素和代谢因素。
Diabetes Care. 2010 Feb;33(2):356-60. doi: 10.2337/dc09-1196. Epub 2009 Oct 30.
8
Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis.妊娠期糖尿病后患2型糖尿病：一项系统评价与荟萃分析
Lancet. 2009 May 23;373(9677):1773-9. doi: 10.1016/S0140-6736(09)60731-5.
9
Pregnancy plasma glucose levels exceeding the American Diabetes Association thresholds, but below the National Diabetes Data Group thresholds for gestational diabetes mellitus, are related to the risk of neonatal macrosomia, hypoglycaemia and hyperbilirubinaemia.孕期血糖水平超过美国糖尿病协会的阈值，但低于美国国家糖尿病数据组关于妊娠期糖尿病的阈值，这与新生儿巨大儿、低血糖和高胆红素血症的风险相关。
Diabetologia. 2007 Feb;50(2):298-306. doi: 10.1007/s00125-006-0517-8. Epub 2006 Nov 14.
10
Body weight and subsequent diabetes mellitus.体重与后续的糖尿病
JAMA. 1982 Aug 27;248(8):949-52.

24-28 周空腹血糖筛查妊娠期糖尿病：来自中国的新证据。

Fasting plasma glucose at 24-28 weeks to screen for gestational diabetes mellitus: new evidence from China.

机构信息

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

出版信息

Diabetes Care. 2013 Jul;36(7):2038-40. doi: 10.2337/dc12-2465. Epub 2013 Mar 27.

DOI:10.2337/dc12-2465
PMID:23536582
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3687275/
Abstract

OBJECTIVE

To evaluate the usefulness of a fasting plasma glucose (FPG) at 24-28 weeks' gestation to screen for gestational diabetes mellitus (GDM).

RESEARCH DESIGN AND METHODS

The medical records and results of a 75-g 2-h oral glucose tolerance test (OGTT) of 24,854 pregnant women without known pre-GDM attending prenatal clinics in 15 hospitals in China were examined.

RESULTS

FPG cutoff value of 5.1 mmol/L identified 3,149 (12.1%) pregnant women with GDM. FPG cutoff value of 4.4 mmol/L ruled out GDM in 15,369 (38.2%) women. With use of this cutoff point, 12.2% of patients with mild GDM will be missed. The positive predictive value is 0.322, and the negative predictive value is 0.928.

CONCLUSIONS

FPG at 24-28 weeks' gestation could be used as a screening test to identify GDM patients in low-resource regions. Women with an FPG between ≥4.4 and ≤5.0 mmol/L would require a 75-g OGTT to diagnose GDM. This would help to avoid approximately one-half (50.3%) of the formal 75-g OGTTs in China.

摘要

目的

评估妊娠 24-28 周时的空腹血糖（FPG）在筛查妊娠期糖尿病（GDM）方面的作用。

研究设计和方法

对中国 15 家医院的 24854 名无已知孕前 GDM 的孕妇的病历和 75g 2 小时口服葡萄糖耐量试验（OGTT）结果进行了检查。

结果

FPG 截断值为 5.1mmol/L 时，可诊断出 3149 名（12.1%）患有 GDM 的孕妇。FPG 截断值为 4.4mmol/L 时，可排除 15369 名（38.2%）孕妇的 GDM。使用该截断点，将错过 12.2%的轻度 GDM 患者。阳性预测值为 0.322，阴性预测值为 0.928。

结论

妊娠 24-28 周时的 FPG 可作为一种筛查试验，用于识别资源匮乏地区的 GDM 患者。FPG 在 4.4mmol/L 至 5.0mmol/L 之间的女性需要进行 75g OGTT 以诊断 GDM。这将有助于避免在中国进行的约一半（50.3%）正式 75g OGTT。