Braverman D Z, Stankiewicz H, Goldstein R, Patz J K, Morali G A, Jacobsohn W Z
Department of Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel.
Am J Gastroenterol. 1990 Jun;85(6):723-6.
Ornithine decarboxylase (ODC) is the first and rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines have been studied as potential markers of neoplastic diseases, including colonic cancer. Previous studies have pointed out the possible value of this enzyme as a biochemical marker of colonic neoplasia, we studied 100 patients undergoing diagnostic total colonoscopy. There were 40 normal controls and 20 patients in each of the following groups: 1) family members of patients diagnosed as having colonic tumors, 2) patients with adenomas, and 3) patients with colonic adenocarcinoma. Six forceps biopsies were obtained from the normal-appearing sigmoid mucosa for the analysis of ODC. No difference was found among the four groups studied. We therefore conclude that ODC is unreliable for clinical use as a biochemical marker for the identification of population groups at risk for colonic neoplasia.
鸟氨酸脱羧酶（ODC）是多胺生物合成途径中的首个限速酶。多胺已被作为包括结肠癌在内的肿瘤性疾病的潜在标志物进行研究。先前的研究指出了这种酶作为结肠肿瘤生化标志物的可能价值，我们对100例接受诊断性全结肠镜检查的患者进行了研究。有40名正常对照者以及以下每组20例患者：1）被诊断患有结肠肿瘤患者的家庭成员，2）腺瘤患者，以及3）结肠腺癌患者。从外观正常的乙状结肠黏膜获取6块钳取活检组织用于ODC分析。在所研究的四组之间未发现差异。因此，我们得出结论，ODC作为一种用于识别有结肠肿瘤风险人群的生化标志物，在临床应用中不可靠。
