Department of Neurosciences and Imaging, University of Chieti, Chieti, Italy.
High Alt Med Biol. 2013 Mar;14(1):78-9. doi: 10.1089/ham.2012.1082.
In 1898, Angelo Mosso (1846-1910) used his low-pressure chambers to carry out some remarkable experiments that are not well known. Paul Bert (1833-1886) had previously demonstrated that the deleterious effects of high altitude were due to low PO2, but this conclusion was disputed by many of the eminent scientists of the day. Mosso believed that the physiological effects of high altitude were caused by a low PCO2 (acapnia) and he made a series of low-pressure chamber experiments to test this. In some studies he added oxygen to the air in the chambers so that he could study the effects of extreme hypobaria; in one experiment he survived a barometric pressure of only 192 mm Hg equivalent to an altitude of about 10,800 m. Some of his experiments were observed by his daughter Mimí who wrote a colorful account in her book dedicated to her father "Un cercatore d'ignoto" (A seeker of the unknown).
1898 年，安杰洛·莫索（1846-1910 年）使用低压室进行了一些鲜为人知的非凡实验。保罗·伯特（1833-1886 年）曾证明，高海拔的有害影响是由于低 PO2 引起的，但这一结论受到当时许多杰出科学家的质疑。莫索认为，高海拔的生理影响是由低 PCO2（呼吸性碱中毒）引起的，他为此进行了一系列低压室实验。在一些研究中，他在室内空气中添加了氧气，以便研究极端低气压的影响；在一项实验中，他在气压仅为 192 毫米汞柱的环境中存活下来，相当于约 10800 米的海拔高度。他的一些实验由他的女儿米米观察，她在一本献给父亲的书中生动地描述了这些实验，书名为“Un cercatore d'ignoto”（一个探索未知的人）。
