University of Washington and Seattle Children's Hospital, Seattle, Washington 98195, USA.
Annu Rev Clin Psychol. 2013;9:555-87. doi: 10.1146/annurev-clinpsy-050212-185627.
Schizophrenia and autism have been linked since their earliest descriptions. Both are disorders of cerebral specialization originating in the embryonic period. Genetic, molecular, and cytologic research highlights a variety of shared contributory mechanisms that may lead to patterns of abnormal connectivity arising from altered development and topology. Overt behavioral pathology likely emerges during or after neurosensitive periods in which resource demands overwhelm system resources and the individual's ability to compensate using interregional activation fails. We are at the threshold of being able to chart autism and schizophrenia from the inside out. In so doing, the door is opened to the consideration of new therapeutics that are developed based upon molecular, synaptic, and systems targets common to both disorders.
精神分裂症和自闭症自其最初描述以来就一直有关联。这两种疾病都是起源于胚胎期的大脑特化障碍。遗传、分子和细胞学研究强调了多种共同的促成机制，这些机制可能导致异常连接模式的出现，这些模式源于发育和拓扑结构的改变。明显的行为病理学可能在神经敏感时期出现，在此期间，资源需求超过系统资源，而个体使用区域间激活来补偿的能力失败。我们正处于能够从内部绘制自闭症和精神分裂症图谱的门槛上。这样做，就为考虑新的治疗方法打开了大门，这些治疗方法是基于两种疾病共有的分子、突触和系统靶点开发的。
