Laboratory of Neurosciences, National Institute on Aging, Intramural Research Program, 251 Bayview Blvd., Baltimore, MD 21224, USA.
Biochem Biophys Res Commun. 2013 Apr 19;433(4):602-6. doi: 10.1016/j.bbrc.2013.03.041. Epub 2013 Mar 26.
Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cellular stress response pathway involved in neuroprotection. We previously screened several natural phytochemicals and identified plumbagin as a novel activator of the Nrf2/ARE pathway that can protect neurons against ischemic injury. Here we extended our studies to natural and synthetic derivatives of plumbagin. We found that 5,8-dimethoxy-1,4-naphthoquinone (naphthazarin) is a potent activator of the Nrf2/ARE pathway, up-regulates the expression of Nrf2-driven genes in primary neuronal and glial cultures, and protects neurons against glutamate-induced excitotoxicity.
核因子 E2 相关因子 2 (Nrf2)/抗氧化反应元件 (ARE) 通路是一种重要的细胞应激反应通路，参与神经保护。我们之前筛选了几种天然植物化学物质，发现并确认白花丹素是 Nrf2/ARE 通路的一种新型激活剂，可保护神经元免受缺血性损伤。在这里，我们将研究扩展到白花丹素的天然和合成衍生物。我们发现 5,8-二甲氧基-1,4-萘醌（萘满素）是 Nrf2/ARE 通路的有效激活剂，可上调原代神经元和神经胶质细胞中 Nrf2 驱动基因的表达，并防止神经元免受谷氨酸诱导的兴奋性毒性。
