Holroyde M C, Eyre P
Immunology. 1976 Aug;31(2):167-70.
Sensitized bovine granulocytes release histamine when exposed to specific antigen. In comparison with in vitro systems in several other species, the modulation of this release by adrenergic agents is unique. Beta-Adrenoceptor stimulation potentiates (rather than inhibits), whereas alpha-adrenoceptor stimulation inhibits (rather than potentiates) histamine release. Adrenaline, which is generally considered to be a physiological antagonist of the anaphylactic reaction, potentiated histamine release in this study. Dopamine, which is present in high concentration in bovine mast cells, was without effect. The results are discussed in terms of the possible role of granulocytes in bovine hypersensitivity.
致敏的牛粒细胞在接触特定抗原时会释放组胺。与其他几种物种的体外系统相比，肾上腺素能药物对这种释放的调节是独特的。β-肾上腺素能受体刺激会增强（而非抑制）组胺释放，而α-肾上腺素能受体刺激则抑制（而非增强）组胺释放。通常被认为是过敏反应生理拮抗剂的肾上腺素，在本研究中增强了组胺释放。在牛肥大细胞中高浓度存在的多巴胺则没有作用。根据粒细胞在牛超敏反应中可能的作用对结果进行了讨论。
