组胺从牛白细胞的免疫性释放。异常的肾上腺素能调节。

Immunological release of histamine from bovine leucocytes. Unusual adrenergic modulation.

作者信息

Holroyde M C, Eyre P

出版信息

Immunology. 1976 Aug;31(2):167-70.

PMID:60282

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445125/

Abstract

Sensitized bovine granulocytes release histamine when exposed to specific antigen. In comparison with in vitro systems in several other species, the modulation of this release by adrenergic agents is unique. Beta-Adrenoceptor stimulation potentiates (rather than inhibits), whereas alpha-adrenoceptor stimulation inhibits (rather than potentiates) histamine release. Adrenaline, which is generally considered to be a physiological antagonist of the anaphylactic reaction, potentiated histamine release in this study. Dopamine, which is present in high concentration in bovine mast cells, was without effect. The results are discussed in terms of the possible role of granulocytes in bovine hypersensitivity.

摘要

致敏的牛粒细胞在接触特定抗原时会释放组胺。与其他几种物种的体外系统相比，肾上腺素能药物对这种释放的调节是独特的。β-肾上腺素能受体刺激会增强（而非抑制）组胺释放，而α-肾上腺素能受体刺激则抑制（而非增强）组胺释放。通常被认为是过敏反应生理拮抗剂的肾上腺素，在本研究中增强了组胺释放。在牛肥大细胞中高浓度存在的多巴胺则没有作用。根据粒细胞在牛超敏反应中可能的作用对结果进行了讨论。

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本文引用的文献

1

A method for the fluorometric assay of histamine in tissues.一种用于组织中组胺荧光测定的方法。

J Pharmacol Exp Ther. 1959 Nov;127:182-6.

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Release of dopamine from bovine lung by specific antigen and by compound 48-80.特定抗原和化合物48-80促使牛肺释放多巴胺。

Br J Pharmacol. 1971 Jul;42(3):423-7. doi: 10.1111/j.1476-5381.1971.tb07127.x.

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Catecholamine release during anaphylactic shock in guinea pigs.

Naunyn Schmiedebergs Arch Pharmakol. 1971;270(4):326-34. doi: 10.1007/BF01002344.

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Adrenergic receptors in the veins of the dog.狗静脉中的肾上腺素能受体。

Eur J Pharmacol. 1969 Jan;5(2):133-40. doi: 10.1016/0014-2999(69)90021-1.

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Release of catecholamines in the guinea-pig by substances involved in anaphylaxis.过敏反应相关物质导致豚鼠儿茶酚胺的释放。

Nature. 1967 Feb 25;213(5078):838-40. doi: 10.1038/213838a0.

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Hematological and pathological changes in acute systemic anaphylaxis in calves: effects of pharmacological agents.犊牛急性全身性过敏反应中的血液学和病理学变化：药理制剂的作用

Can J Comp Med. 1973 Apr;37(2):119-29.

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Immunological release of histamine and slow reacting substance of anaphylaxis from human lung.组胺及过敏反应迟缓反应物质从人肺组织中的免疫性释放

J Exp Med. 1972 Sep 1;136(3):556-67. doi: 10.1084/jem.136.3.556.

8

Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3',5'-adenosine monophosphate in human leukocytes.体外过敏性组胺释放的药理学控制：3',5'-单磷酸腺苷在人白细胞中的抑制作用证据。

J Immunol. 1972 Mar;108(3):695-705.

9

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Inhibition of the anaphylactic mechanism by sympathomimetic amines.

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