标准剂量与低剂量术中丝裂霉素C预防准分子激光原位角膜磨镶术后角膜雾状混浊的比较。

Comparison of standard and low dose intraoperative mitomycin C in prevention of corneal hazeafter photorefractive keratectomy.

作者信息

Razmjoo Hassan, Kooshanmehr Mohammad Reza, Peyman Alireza, Kor Zahra, Mohammadesmaeil Erfan

机构信息

Department of Ophthalmology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Int J Prev Med. 2013 Feb;4(2):204-7.

PMID:23543763

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3604854/

Abstract

BACKGROUND

This study aimed to compare two doses of Mitomycin C in reducing haze formation after photorefractive keratectomy.

METHODS

170 eyes of 85 patients enrolled; in each patient one eye randomly assigned to be treated by low dose intraoperative MMC (LDMMC) and other eye by standard dose MMC (SDMMC). Then the patients were followed up to 6 months and refraction, Uncorrected Distant Visual Acuity (UCDVA), Best Corrected Distant Visual Acuity (BCDVA) and haze formation submitted in each postoperative exam.

RESULTS

The mean preoperative refraction in LDMMC eyes was -3.08 (SD 1.65) sphere and 0.92 (SD 0.88) cylinder. These values for SDMMC eyes were -3.25 (SD 1.80) sphere and 0.81 (SD 0.84) cylinder. Mean postoperative sphere in LDMMC group was -0.132 (SD 0.503) and -0.138 (SD 0.484) in 3 and 6 months after PRK. These results was -0.041 (SD 0.501) and -0.076 (SD 0.489) for SDMMC group. Mean postoperative cylinder 3 and 6 month after PRK was 0.435 (SD 0.218) and 0.423 (SD 0.255). In LDMMC group and 0.435 (SD 0.247) and 0.426 (SD 0.261) in SDMMC group. In third month 14 eyes in LDMMC group presented with grade 1 score of clinical haze. From these eyes only 2 still had this haze after 6 month. 7 eyes in SDMMC group had grade 1 clinical haze at third month- but no clinical haze was seen at the end of 6(th) month.

CONCLUSION

The results of the two doses of Mitomycin C were not significant. We suggest to use the lower dose to reduce its side effects.

摘要

背景

本研究旨在比较两种剂量的丝裂霉素C在减少准分子激光角膜切削术后 haze 形成方面的效果。

方法

纳入85例患者的170只眼；每位患者的一只眼随机分配接受低剂量术中丝裂霉素C（LDMMC）治疗，另一只眼接受标准剂量丝裂霉素C（SDMMC）治疗。然后对患者进行6个月的随访，并在每次术后检查时记录屈光、未矫正远视力（UCDVA）、最佳矫正远视力（BCDVA）和 haze 形成情况。

结果

LDMMC组眼术前平均球镜度数为-3.08（标准差1.65），柱镜度数为0.92（标准差0.88）。SDMMC组眼的这些值分别为-3.25（标准差1.80）球镜和0.81（标准差0.84）柱镜。PRK术后3个月和6个月，LDMMC组平均球镜度数分别为-0.132（标准差0.503）和-0.138（标准差0.484）。SDMMC组的这些结果分别为-0.041（标准差0.501）和-0.076（标准差0.489）。PRK术后3个月和6个月，LDMMC组平均柱镜度数分别为0.435（标准差0.218）和0.423（标准差0.255）。SDMMC组分别为0.435（标准差0.247）和0.426（标准差0.261）。在第3个月，LDMMC组有14只眼出现临床 haze 评分为1级。6个月后，这些眼中只有2只仍有 haze。SDMMC组在第3个月有7只眼出现1级临床 haze，但在第6个月末未见临床 haze。