de Chadarévian J P, Pattisapu J V, Faerber E N
Department of Pediatric Anatomical Pathology, St. Christopher's Hospital for Children, Philadelphia, PA 19133.
Cancer. 1990 Jul 1;66(1):173-9. doi: 10.1002/1097-0142(19900701)66:1<173::aid-cncr2820660131>3.0.co;2-h.
The first detailed ultrastructural study of a superficial desmoplastic cerebral astrocytoma of infancy is reported. This is a neoplasm which mimics a mesenchymal tumor, originally described in 1984 under the name of "superficial cerebral astrocytoma attached to dura." This tumor, which is believed to have a good prognosis, was resected from the frontoparietal region of a 6.5-month-old girl, in whom it had presented as a large densely enhancing vascular and cystic mass. The ultrastructure of the tumor appeared to be distinctive, characterized by the absence of neuronal elements, and the presence of large amounts of redundant and sometimes extensively duplicated basal laminal material and collagen between nonpleomorphic and nonlipidized astrocytes, corresponding to the reticulin fibers seen by light microscopic analysis between the S-100 protein and glial fibrillary acidic protein (GFAP)-positive cells. The features of the tumor, its differential diagnosis, and its relationship to other pediatric supratentorial tumors are discussed.
本文报道了首例婴儿期浅表性促纤维增生性脑星形细胞瘤的详细超微结构研究。这是一种类似间叶性肿瘤的肿瘤，最初于1984年以“附着于硬脑膜的浅表性脑星形细胞瘤”之名被描述。该肿瘤被认为预后良好，从一名6.5个月大女童的额顶叶区域切除，肿瘤表现为一个大的、强化明显的血管性和囊性肿块。肿瘤的超微结构似乎具有独特性，其特征为无神经元成分，在非多形性且非脂质化的星形胶质细胞之间存在大量多余的、有时广泛重复的基底膜物质和胶原，这与光镜分析中在S-100蛋白和胶质纤维酸性蛋白（GFAP）阳性细胞之间所见的网状纤维相对应。文中讨论了该肿瘤的特征、鉴别诊断及其与其他儿童幕上肿瘤的关系。
