Department of Pathology, University of Utah School of Medicine and ARUP Laboratories, Salt Lake City, Utah 84112, USA.
Arch Pathol Lab Med. 2013 Apr;137(4):566-75. doi: 10.5858/arpa.2012-0199-RA.
The quality of diagnostic accuracy studies is determined by 2 key factors: risk of bias and comparability. Bias can distort accuracy estimates and poor reporting impairs comparability. While diagnostic accuracy studies for fine-needle aspiration cytology (FNAC) are frequently published, the methodologic issues associated with this body of literature have never been reviewed.
To assess the quality of design and reporting of diagnostic test accuracy studies in FNAC.
Diagnostic accuracy studies were identified by a Medline (US National Library of Medicine) search. Sixty-four FNAC diagnostic test accuracy studies were randomly selected for structured review with the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) survey. Studies were divided between 2 time periods: 2000-2001 and 2009-2011.
Diagnostic test accuracy studies of FNAC suffer from numerous deficiencies in study design, which negatively affect the reliability of accuracy estimates.
诊断准确性研究的质量取决于两个关键因素：偏倚风险和可比性。偏倚会扭曲准确性估计，而报告质量差则会影响可比性。虽然细针抽吸细胞学（FNAC）的诊断准确性研究经常发表，但该领域文献的方法学问题从未得到审查。
评估 FNAC 中诊断检测准确性研究的设计和报告质量。
通过 Medline（美国国立医学图书馆）检索来确定诊断准确性研究。随机选择了 64 项 FNAC 诊断检测准确性研究，并用 QUADAS 调查进行了结构化综述。研究分为两个时间段：2000-2001 年和 2009-2011 年。
FNAC 的诊断检测准确性研究在研究设计上存在许多缺陷，这对准确性估计的可靠性产生了负面影响。
