Hofer Silvia, Pestalozzi Bernhard C
Department of Oncology, University Hospital, Raemistrasse 100, 8091 Zürich, Switzerland.
Eur J Pharmacol. 2013 Oct 5;717(1-3):84-7. doi: 10.1016/j.ejphar.2012.11.068. Epub 2013 Mar 30.
Breast cancer represents the second most frequent cause of brain metastases. Treatment planning should consider several tumor and patient factors to estimate prognosis based on the Karnofsky Performance Status (KPS), age, extent of extra-cerebral disease as well as genetic subtype. When systemic disease is under control patients with up to three metastases qualify for local therapy, such as surgical excision or stereotactic radiotherapy. After the local treatment the addition of whole brain radiation therapy may be postponed until disease progression in the brain is observed and overall survival will not be compromised. Asymptomatic brain metastases may be first approached with a systemic treatment to which the primary tumor is considered to be sensitive.
乳腺癌是脑转移的第二大常见病因。治疗方案的制定应综合考虑多种肿瘤和患者因素，以根据卡氏功能状态评分（KPS）、年龄、脑外疾病范围以及基因亚型来评估预后。当全身疾病得到控制时，脑转移灶不超过三个的患者适合接受局部治疗，如手术切除或立体定向放射治疗。局部治疗后，全脑放疗可推迟至观察到脑部疾病进展且不影响总生存期时进行。无症状脑转移可首先采用对原发肿瘤敏感的全身治疗。
