Nishida Shingo, Hitsumoto Akiko, Namba Kazuyoshi, Usui Akira, Inoue Yuichi
Yoyogi Sleep Disorder Center, Japan.
Intern Med. 2013;52(7):815-8. doi: 10.2169/internalmedicine.52.9013. Epub 2013 Apr 1.
Our patient had secondary restless legs syndrome (RLS) in the left lower limb caused by end-stage renal disease (ESRD). Severe RLS symptoms persisted even after amputation of the affected limb. Considering that oral administration of a dopamine receptor agonist was effective in treating the RLS in the phantom limb in this case, dysfunction of the central dopaminergic system was thought to be involved in the phantom limb-RLS mechanism. The persistence of RLS symptoms even after amputation of the affected limb suggests that the area responsible for ESRD-related RLS symptoms exists at the spinal level or in the higher central nervous system.
我们的患者患有由终末期肾病（ESRD）引起的左下肢继发性不安腿综合征（RLS）。即使在受影响肢体截肢后，严重的RLS症状仍持续存在。考虑到在这种情况下口服多巴胺受体激动剂对治疗幻肢中的RLS有效，中枢多巴胺能系统功能障碍被认为与幻肢-RLS机制有关。即使在受影响肢体截肢后RLS症状仍持续存在，这表明负责ESRD相关RLS症状的区域存在于脊髓水平或更高的中枢神经系统中。
