荟萃分析表明，XRCC1 - 399基因多态性与肝细胞癌易感性之间不存在关联。

Meta-analysis demonstrates lack of a relationship between XRCC1-399 gene polymorphisms and susceptibility to hepatocellular carcinoma.

作者信息

Zeng X Y, Huang J M, Xu J W, Xu Y, Yu H P, Ji L, Qiu X Q

机构信息

Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.

出版信息

Genet Mol Res. 2013 Jun 13;12(2):1916-23. doi: 10.4238/2013.March.15.5.

DOI:10.4238/2013.March.15.5

PMID:23546985

Abstract

XRCC1-399 allele polymorphisms have been reported to be associated with susceptibility to hepatocellular carcinoma (HCC), but the conclusions of the various studies have been inconsistent. We conducted a meta-analysis of available studies to determine whether XRCC1-399 alleles influence susceptibility to hepatocellular carcinoma. We searched English-language databases, including PubMed, Medline and Embase, using terms such as "hepatocellular carcinoma" (or "HCC"), "X-ray repair cross-complementing group 1" (or "XRCC1") and "genetic polymorphism" (or "SNP"), among others; we also searched Chinese-language databases, including CNKI, VIP, Wanfang Data, and CBM, using terms such as "ganai", "ganxibaoai", "ganzhongliu", "duotaixing", and "X-xian xiufu jiaocha hubu jiyin 1". Eight independent studies, including 1604 HCC cases and 2185 controls, were included. The pooled odds ratio for XRCC1-399 was 0.99 (95% confidence interval = 0.75-1.31). We conclude that XRCC1- 399 gene polymorphisms are unrelated to risk for HCC.

摘要

据报道，XRCC1 - 399等位基因多态性与肝细胞癌（HCC）易感性相关，但各项研究结论并不一致。我们对现有研究进行了荟萃分析，以确定XRCC1 - 399等位基因是否影响肝细胞癌易感性。我们使用了“肝细胞癌”（或“HCC”）、“X射线修复交叉互补组1”（或“XRCC1”）和“基因多态性”（或“SNP”）等术语检索了英文数据库，包括PubMed、Medline和Embase；我们还使用了“肝癌”、“肝细胞癌”、“肝肿瘤”、“多态性”和“X线修复交叉互补基因1”等术语检索了中文数据库，包括中国知网、维普资讯、万方数据和中国生物医学文献数据库。纳入了8项独立研究，包括1604例HCC病例和2185例对照。XRCC1 - 399的合并比值比为0.99（95%置信区间 = 0.75 - 1.31）。我们得出结论，XRCC1 - 399基因多态性与HCC风险无关。