Stevens J B, Abdallah B Y, Liu G, Horne S D, Bremer S W, Ye K J, Huang J Y, Kurkinen M, Ye C J, Heng H H Q
Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Mich. 48201, USA.
Cytogenet Genome Res. 2013;139(3):164-73. doi: 10.1159/000348679. Epub 2013 Apr 3.
Cell death constitutes a number of heterogeneous processes. Despite the dynamic nature of cell death, studies of cell death have primarily focused on apoptosis, and cell death has often been viewed as static events occurring in linear pathways. In this article we review cell death heterogeneity with specific focus on 4 aspects of cell death: the type of cell death; how it is induced; its mechanism(s); the results of cell death, and the implications of cell death heterogeneity for both basic and clinical research. This specifically reveals that cell death occurs in multiple overlapping forms that simultaneously occur within a population. Network and pathway heterogeneity in cell death is also discussed. Failure to integrate cell death heterogeneity within analyses can lead to inaccurate predictions of the amount of cell death that takes place in a tumor. Similarly, many molecular methods employed in cell death studies homogenize a population removing heterogeneity between individual cells and can be deceiving. Finally, and most importantly, cell death heterogeneity is linked to the formation of new genome systems through induction of aneuploidy and genome chaos (rapid genome reorganization).
细胞死亡构成了许多异质性过程。尽管细胞死亡具有动态性质，但对细胞死亡的研究主要集中在凋亡上，并且细胞死亡常常被视为发生在线性途径中的静态事件。在本文中，我们回顾细胞死亡的异质性，特别关注细胞死亡的四个方面：细胞死亡的类型；其诱导方式；其机制；细胞死亡的结果，以及细胞死亡异质性对基础研究和临床研究的意义。这具体揭示了细胞死亡以多种重叠形式发生，这些形式在一个群体中同时出现。还讨论了细胞死亡中的网络和途径异质性。在分析中未能整合细胞死亡异质性可能导致对肿瘤中发生的细胞死亡量的不准确预测。同样，细胞死亡研究中使用的许多分子方法会使群体同质化，消除单个细胞之间的异质性，可能具有误导性。最后，也是最重要的，细胞死亡异质性通过非整倍体诱导和基因组混乱（快速基因组重组）与新基因组系统的形成相关联。
