Department of Mathematics, University of Nebraska at Omaha, Omaha, Nebraska, USA.
Clin Pharmacol Ther. 2013 May;93(5):393-5. doi: 10.1038/clpt.2013.41. Epub 2013 Feb 20.
Diseases are often a result of multiple malfunctions in complex, nonlinear biological/biochemical networks. As such, these processes are far more complicated to understand because they tend to give rise to functions that are emergent in nature, i.e., higher-level (mal)functions that are more than the sum of their parts. Systems biology provides a new approach to understanding biological systems and diseases from a holistic perspective.
疾病通常是复杂、非线性生物/生化网络中多个故障的结果。因此,这些过程理解起来要复杂得多,因为它们往往会产生自然涌现的功能,即高于其组成部分的(异常)功能。系统生物学从整体的角度为理解生物系统和疾病提供了一种新方法。