Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, NCI, 6120 Executive Blvd., Bethesda, MD 20892, USA.
Cancer Epidemiol Biomarkers Prev. 2013 Apr;22(4):533-9. doi: 10.1158/1055-9965.EPI-12-1348.
We review monoclonal B-cell lymphocytosis (MBL) as a precursor to chronic lymphocytic leukemia and monoclonal gammopathy of undetermined significance (MGUS) as a precursor to plasma cell disorders. These conditions are present in the general population and increase with age. These precursors aggregate with lymphoproliferative malignancies in families suggesting shared inheritance. MBL and MGUS may share some of the same risk factors as their related malignancies but data are limited. Although these conditions are characterized by enhanced risk for the associated malignancy, the majority of individuals with these conditions do not progress to malignancy. A key focus for current work is to identify markers that predict progression to malignancy.
我们回顾了单克隆 B 细胞淋巴增生症（MBL）作为慢性淋巴细胞白血病的前体，以及单克隆免疫球蛋白血症（MGUS）作为浆细胞疾病的前体。这些情况在一般人群中存在，并随着年龄的增长而增加。这些前体与家族中的淋巴增生性恶性肿瘤聚集在一起，表明存在共同遗传。MBL 和 MGUS 可能与它们相关的恶性肿瘤具有一些相同的危险因素，但数据有限。尽管这些情况具有与相关恶性肿瘤风险增加的特征，但大多数患有这些疾病的人不会进展为恶性肿瘤。目前工作的一个重点是确定可预测向恶性肿瘤进展的标志物。
