Mehdipour Dalivand Maryam, Tizro Parastou, Partain Julie, Aggarwal Anita, Lichy Jack, Mot Ara Francisco, Nava Victor E
The George Washington University, Department of Pathology, Washington, DC, USA.
Oregon Health and Science University, Portland, OR, USA.
Case Rep Hematol. 2022 Apr 21;2022:1132544. doi: 10.1155/2022/1132544. eCollection 2022.
Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.
虽然急性淋巴细胞白血病（ALL）和单克隆B细胞淋巴细胞增多症（MBL）是常见的肿瘤，但同时出现的情况非常罕见。在此，我们报告一名78岁非裔美国男性体内同时循环存在两种不同的B细胞克隆，即MBL和B-ALL。详细的分子特征分析显示存在一种不寻常的MPL（T487I）点突变以及未突变的VH4-39。经过非标准化疗后，患者处于形态学缓解状态。这些发现可能会激发进一步的研究以阐明血液肿瘤的发病机制。
